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A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease
Zhong, Hai-Jing1; Wang, Wanhe2; Kang, Tian-Shu1; Yan, Hui3; Yang, Yali3; Xu, Lipeng3; Wang, Yuqiang3; Ma, Dik-Lung2; Leung, Chung-Hang1
2017-01-12
Source PublicationJOURNAL OF MEDICINAL CHEMISTRY
ISSN0022-2623
Volume60Issue:1Pages:497-503
Abstract

We report herein the identification of the rhodium(III) complex [Rh(phq)(2)(MOPIP)](+) (1): as a potent and selective ATP-competitive neural precursor cell expressed developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory, activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.

DOI10.1021/acs.jmedchem.6b00250
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000392035100034
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:27   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhong, Hai-Jing; Ma, Dik-Lung; Leung, Chung-Hang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao P. R China
2.Department of Chemistry, Hong Kong Baptist University, T1303, Cha Chi-Ming Science Tower, Kowloon Tong, Hong Kong, P. R. China
3.Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhong, Hai-Jing,Wang, Wanhe,Kang, Tian-Shu,et al. A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease[J]. JOURNAL OF MEDICINAL CHEMISTRY,2017,60(1):497-503.
APA Zhong, Hai-Jing.,Wang, Wanhe.,Kang, Tian-Shu.,Yan, Hui.,Yang, Yali.,...&Leung, Chung-Hang.(2017).A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease.JOURNAL OF MEDICINAL CHEMISTRY,60(1),497-503.
MLA Zhong, Hai-Jing,et al."A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease".JOURNAL OF MEDICINAL CHEMISTRY 60.1(2017):497-503.
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