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Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer
Chen, Xin1,2; Oppenheim, Joost J.2
2017-01-17
Source PublicationSCIENCE SIGNALING
ISSN1945-0877
Volume10Issue:462
Abstract

Tumor necrosis factor receptor type II (TNFR2) is expressed both by some cancer cells and by tumor-infiltrating immunosuppressive CD4(+)FoxP3(+) regulatory T cells (T-regs). TNFR2 stimulates the activation and proliferation of T-regs, a major checkpoint of antitumor immune responses, and promotes cancer cell survival and tumor growth. In this issue of Science Signaling, Torrey et al. found that dominant antagonistic antibodies against human TNFR2 may be a potential therapy for ovarian cancer patients by simultaneously suppressing T-reg activity and inducing the death of the cancer cells.

DOI10.1126/scisignal.aal2328
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000393784200001
PublisherAMER ASSOC ADVANCEMENT SCIENCE
The Source to ArticleWOS
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao S.A.R. 999078, China.
2.Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Xin,Oppenheim, Joost J.. Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer[J]. SCIENCE SIGNALING,2017,10(462).
APA Chen, Xin,&Oppenheim, Joost J..(2017).Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer.SCIENCE SIGNALING,10(462).
MLA Chen, Xin,et al."Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer".SCIENCE SIGNALING 10.462(2017).
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