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Physical comorbidities in older adults receiving antidepressants in Asia
Zhong, Xiao-Mei1,2; Min DONG2; Fei WANG2; Qinge ZHANG3; Gabor S. UNGVARI4; Chee H. NG5; Helen F.K. CHIU6; Tian-Mei SI7; Kang SIM8; Ajit AVASTHI9; Sandeep GROVER9; Mian-Yoon CHONG10; Kok-Yoon CHEE11; Shigenobu KANBA12; Min-Soo LEE13; Shu-Yu YANG14; Pichet UDOMRATN15; Roy A. KALLIVAYALIL16; Andi J. TANRA17; Margarita M. MARAMIS18; Winston W. SHEN19; Norman SARTORIUS20; Rathi MAHENDRAN21; Chay-Hoon TAN22; Naotaka SHINFUKU23; Yu-Tao XIANG2


The present study explored the patterns of physical comorbidities and their associated demographic and clinical factors in older psychiatric patients prescribed with antidepressants in Asia.


Demographic and clinical information of 955 older adults were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Standardized data collection procedure was used to record demographic and clinical data.


Proportion of physical comorbidities in this cohort was 44%. Multiple logistic regression analyses showed that older age (OR=1.7, P<0.001), higher number of depressive symptoms (OR=1.09, P=0.016), being treated in psychiatric hospital (OR=0.5, P=0.002), living in high income countries/territories (OR=2.4, P=0.002), use of benzodiazepines (OR=1.4, P=0.013) and diagnosis of other psychiatric disorders' (except mood, anxiety disorders and schizophrenia) (OR=2.7, P<0.001) were significantly associated with physical comorbidities.


Physical comorbidities in older patients prescribed with antidepressants were common in Asia. Integrating physical care into the treatment of older psychiatric patients should be urgently considered.

KeywordAntidepressant Asia Older Adults Physical Comorbidity
URLView the original
Indexed BySCIE
WOS Research AreaGeriatrics & Gerontology ; Psychiatry
WOS SubjectGeriatrics & Gerontology ; Psychiatry
WOS IDWOS:000444681800004
The Source to ArticleWOS
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYu-Tao XIANG
Affiliation1.Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Hui Hospital), Guangzhou, China.
2.Unit ofPsychiatry, Faculty of Health Sciences, University ofMacau, Macao SAR
3.he National ClinicalResearch Center for Mental Disorders & BeijingKey Laboratory of Mental Disorders, Beijing And-ing Hospital, Capital Medical University
4.The University of Notre Dame Australia / Gray-lands Hospital, Perth
5.Department of Psychia-try, University of Melbourne, Melbourne, Victoria,Australia
6.Department of Psychiatry, ChineseUniversity of Hong Kong, Hong Kong, China
7.Peking University Institute of Mental Health (thesixth Hospital) & National Clinical Research Centerfor Mental Disorders & the key Laboratory of Men-tal Health, Ministry of Health (Peking University),Beijing
8.Institute of Mental Health, BuangkokView, Buangkok Green Medical Park, Singapore
9.Department of Psychiatry, PostgraduateInstitute of Medical Education and Research, Chan-digarh
10.Department of Psychiatry, Kaohsiung ChangGung Memorial Hospital-Kaohsiung Medical Center and School of Medicine, Chang Gung University , Taiwan
11.Department of Psychiatry & Mental Health, Tunku Abdul Rahman Institute of Neurosciences, Kuala LumpurHospital, Kuala Lumpur, Malaysia
12.Department ofNeuropsychiatry, Kyushu University, Fukuoka, Japan
13.Department of Psychiatry, College of Medicine,Korea University, Seoul, Korea
14.Department of Pharmacy, Taipei CityHospital, Taiwan
15.Department ofPsychiatry, Faculty of Medicine, Prince of SongklaUniversity, Songkhla, Thailand
16.Department of Psychiatry, PushpagiriInstitute of Medical Sciences, Thiruvalla, India
17.Department ofPsychiatry, Hasanuddin University Faculty of Medi-cine, Makassar, Sulawesi Selatan
18.Dr. Soetomo Hospital – Faculty of Medicine, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
19.Departments of Psychiatry, TMU-Wan Fang Medical Center and School of Medicine,Taipei Medical University, Taipei, Taiwan
20.Association for the Improvement of MentalHealth Programmes, Geneva, Switzerland
21.Psychological Medicine, National University of Singapore,Singapore
22.Pharma-cology, National University of Singapore,Singapore
23.International Center for Medical Research, KobeUniversity School of Medicine, Kobe, Japan
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhong, Xiao-Mei,Min DONG,Fei WANG,et al. Physical comorbidities in older adults receiving antidepressants in Asia[J]. PSYCHOGERIATRICS,2018,18(5):351-356.
APA Zhong, Xiao-Mei.,Min DONG.,Fei WANG.,Qinge ZHANG.,Gabor S. UNGVARI.,...&Yu-Tao XIANG.(2018).Physical comorbidities in older adults receiving antidepressants in Asia.PSYCHOGERIATRICS,18(5),351-356.
MLA Zhong, Xiao-Mei,et al."Physical comorbidities in older adults receiving antidepressants in Asia".PSYCHOGERIATRICS 18.5(2018):351-356.
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