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Real-time detection and imaging of copper(II) in cellular mitochondria
Li, Hong1,2; Zhang, Ruilong1,2; Li, Chunxia3; Huang, Bei3; Yu, Tingting1,2; Huang, Xiaodan1,2; Zhang, Xuanjun4; Li, Fei1,2; Zhou, Hongping1,2; Tian, Yupeng1,2
2017-01-21
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
Volume15Issue:3Pages:598-604
Abstract

A triphenylamine-pyridine derivative, viz., a fluorescence probe was designed and synthesized. The probe displayed an "on-off-on" fluorescence switch, upon the sequential addition of Cu2+ and ethylenediaminetetraacetic acid (EDTA). The detection mechanism was confirmed by using UV-vis, fluorescence and H-1 NMR titration spectra. Interestingly, the probe can accumulate in mitochondria, and thus detect Cu2+ in real-time there, which indicated that probe L can be used to monitor intracellular mitochondrial Cu2+ levels. Further understanding of the biological functions of Cu2+ in mitochondria has important implications for treating cancer and other diseases.

DOI10.1039/c6ob02384c
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000394963900016
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Anhui Univ, Coll Chem & Chem Engn, Hefei 230601, Peoples R China
2.Key Lab Funct Inorgan Mat Chem Anhui Prov, Hefei 230601, Peoples R China
3.Anhui Univ, Ctr Stem Cell Res & Transformat Med, Hefei 230601, Peoples R China
4.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Li, Hong,Zhang, Ruilong,Li, Chunxia,et al. Real-time detection and imaging of copper(II) in cellular mitochondria[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(3):598-604.
APA Li, Hong.,Zhang, Ruilong.,Li, Chunxia.,Huang, Bei.,Yu, Tingting.,...&Tian, Yupeng.(2017).Real-time detection and imaging of copper(II) in cellular mitochondria.ORGANIC & BIOMOLECULAR CHEMISTRY,15(3),598-604.
MLA Li, Hong,et al."Real-time detection and imaging of copper(II) in cellular mitochondria".ORGANIC & BIOMOLECULAR CHEMISTRY 15.3(2017):598-604.
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