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Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor beta 1 Activity in Triggering Lung Fibrosis
Wang, Zhenzhen1; Wang, Chunming2; Liu, Shang1; He, Wei1; Wang, Lintao1; Gan, Jingling1; Huang, Zhen1; Wang, Zhenheng1; Wei, Haoyang1; Zhang, Junfeng1,3; Dong, Lei1
2017-02
Source PublicationACS NANO
ISSN1936-0851
Volume11Issue:2Pages:1659-1672
Abstract

A corona is a layer of macromolecules formed on a nanoparticle surface in vivo. It can substantially change the biological identity of nanomaterials and possibly trigger adverse responses from the body tissues. Dissecting the role of the corona in the development of a particular disease may provide profound insights for understanding toxicity of nanomaterials in general. In our present study, we explored the capability of different silica nanoparticles (SiNPs) to induce silicosis in the mouse lung and analyzed the composition of coronas formed on these particles. We found that SiNPs of certain size and surface chemistry could specifically recruit transforming growth factor beta 1 (TGF-beta 1)intotheircorona, which subsequently induces the development of lung fibrosis. Once embedded into the corona on SiNPs, TGF-beta l was remarkably more stable than in its free form, and its fibrosis-triggering activity was significantly prolonged. Our study meaningfully demonstrates that a specific corona component on a certain nanoparticle could initiate a particular pathogenic process in a clinically relevant disease model. Our findings may shed light on the understanding of molecular mechanisms of human health risks correlated with exposure to small-scale substances.

KeywordCorona Silica Nanoparticles Nano-bio Interface Lung Fibrosis Tgf-,Beta 1
DOI10.1021/acsnano.6b07461
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000395357300057
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Co-First AuthorWang, Zhenzhen
Corresponding AuthorWang, Chunming; Zhang, Junfeng; Dong, Lei
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210093, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
3.Jiangsu Provincial Laboratory for Nano-Technology, Nanjing University, Nanjing 210093, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Zhenzhen,Wang, Chunming,Liu, Shang,et al. Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor beta 1 Activity in Triggering Lung Fibrosis[J]. ACS NANO,2017,11(2):1659-1672.
APA Wang, Zhenzhen.,Wang, Chunming.,Liu, Shang.,He, Wei.,Wang, Lintao.,...&Dong, Lei.(2017).Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor beta 1 Activity in Triggering Lung Fibrosis.ACS NANO,11(2),1659-1672.
MLA Wang, Zhenzhen,et al."Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor beta 1 Activity in Triggering Lung Fibrosis".ACS NANO 11.2(2017):1659-1672.
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