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Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists
Vergelli, Claudia; Schepetkin, Igor A.; Ciciani, Giovanna; Cilibrizzi, Agostino; Crocetti, Letizia; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Kirpotina, Liliya N.; Ye, Richard D.; Quinn, Mark T.
2017-02
Source PublicationDRUG DEVELOPMENT RESEARCH
ISSN0272-4391
Volume78Issue:1Pages:49-62
AbstractFormyl peptide receptors (FPRs) are G-protein-coupled receptors that play an important role in the regulation of inflammatory process and cellular dysfunction. In humans, three different isoforms are expressed (FPR1, FPR2, and FPR3). FPR2 appears to be directly involved in the resolution of inflammation, an active process carried out by specific pro-resolving mediators that modulate specific receptors. Previously, we identified 2-arylacetamido pyridazin-3(2H)-ones as FPR1- or FPR2-selective agonists, as well as a large number of mixed-agonists for the three isoforms. Here, we report a new series of 2-arylacetamido pyridazinones substituted at position 5 and their development as FPR agonists. We also synthesized a new series of 2-oxothiazolones bearing a 4-bromophenylacetamido fragment, which was fundamental for activity in the pyridazinone series. The compounds of most interest were 4a, a potent, mixed FPR agonist recognized by all three isotypes (FPR1 EC50=19 nM, FPR2 EC50=43 nM, FPR3 EC50=40 nM), and 4b, which had potent activity and a preference for FPR2 (EC50=13 nM). These novel compounds may represent valuable tools for studying FPR activation and signaling. (C) 2016 Wiley Periodicals, Inc.
Keywordformyl peptide receptor agonist pyridazin-3(2H)-one neutrophil Ca2+flux
DOI10.1002/ddr.21370
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000396995000004
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Vergelli, Claudia,Schepetkin, Igor A.,Ciciani, Giovanna,et al. Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists[J]. DRUG DEVELOPMENT RESEARCH,2017,78(1):49-62.
APA Vergelli, Claudia.,Schepetkin, Igor A..,Ciciani, Giovanna.,Cilibrizzi, Agostino.,Crocetti, Letizia.,...&Quinn, Mark T..(2017).Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists.DRUG DEVELOPMENT RESEARCH,78(1),49-62.
MLA Vergelli, Claudia,et al."Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists".DRUG DEVELOPMENT RESEARCH 78.1(2017):49-62.
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