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Multi-color light-emitting amphiphilic cellulose/conjugated polymers nanomicelles for tumor cell imaging
Zhong, Haoquan; Zhang, Jinming; Guo, Yanzhu; Wang, Lu; Ge, Wenjiao; Chen, Meiwan; Sun, Runcang; Wang, Xiaohui
2017-02
Source PublicationCELLULOSE
ISSN0969-0239
Volume24Issue:2Pages:889-902
AbstractNovel cellulose nanomicelles self-assembled from amphiphilic cellulose-graft-poly(p-dioxanone) (MCC-graft-PPDO) copolymer were used to encapsulate and disperse hydrophobic fluorescent conjugated polymers (FCPs) in water for tumor cell imaging. Three different conjugated polymers were employed to demonstrate the versatility of the cellulose nanomicelles, resulting in highly fluorescent and stable polymeric nanoparticles with different emission wavelengths across the visible spectrum. Owing to the size effect of cellulose nanomicelles, the incorporated conjugated polymers present red-shifted emission to low-energy sites, and the fluorescence self-quenching of conjugated polymers at high concentration can be greatly inhibited. The in vitro studies using the liver cancer Hep3B cells and the breast cancer MAD-MB-231 cells indicate these amphiphilic cellulose/FCPs nanomicelles have negligible cytotoxicity even at high concentration of up to 100 mu g/mL. Moreover, the light-emitting micelles are successfully uptaken by the cancer cells and located at the cytoplasm of the cells, suggesting their great potential for tumor cell imaging and early detection of tumor cells.
KeywordAmphiphilic cellulose derivative Nanomicelles Fluorescent conjugated polymers Tumor cell imaging
DOI10.1007/s10570-016-1126-4
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMaterials Science ; Polymer Science
WOS SubjectMaterials Science, Paper & Wood ; Materials Science, Textiles ; Polymer Science
WOS IDWOS:000394145500032
PublisherSPRINGER
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhong, Haoquan,Zhang, Jinming,Guo, Yanzhu,et al. Multi-color light-emitting amphiphilic cellulose/conjugated polymers nanomicelles for tumor cell imaging[J]. CELLULOSE,2017,24(2):889-902.
APA Zhong, Haoquan.,Zhang, Jinming.,Guo, Yanzhu.,Wang, Lu.,Ge, Wenjiao.,...&Wang, Xiaohui.(2017).Multi-color light-emitting amphiphilic cellulose/conjugated polymers nanomicelles for tumor cell imaging.CELLULOSE,24(2),889-902.
MLA Zhong, Haoquan,et al."Multi-color light-emitting amphiphilic cellulose/conjugated polymers nanomicelles for tumor cell imaging".CELLULOSE 24.2(2017):889-902.
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