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Improved Quantification of Chemical Exchange Saturation Transfer (CEST) MRI by Nonlocal Means
Jing Yuan1; Greta Seng Peng Mok2; Qinwei Zhang3; Yi-Xiang Wang3; Jinyuan Zhou4
2014
Conference Name2014 IEEE Nuclear Science Symposium and Medical Imaging Conference
Source Publication2014 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC)
Conference Date8-15 Nov. 2014
Conference PlaceSeattle, WA, USA
Abstract

Chemical exchange saturation transfer (CEST) MRI offers a powerful molecular imaging tool by exploiting the proton exchanges between free water and labile exchangeable molecules in vivo. Accurate CEST quantification from Z-spectrum analysis, particularly at clinical field strengths, suffers from low contrast-to-noise ratio (CNR). In this study, we proposed the use of non-local means (NLM) for CEST-MRI denoising to improve the CEST contrast quantification. The experimental results showed that the NLM denoising effectively removed noise presented in the low signal-to-noise ratio (SNR) CEST images with high resolution and well preserved the tissue structures. The CEST contrast map generated from the NLM-denoised images was notably improved, which was closer to the map generated from images with 3.5-fold higher SNR and meanwhile had much less partial volume effect. NLM denoising holds great potentials for the clinical CEST-MRI quantification improvement without compromising spatial resolution.

DOIhttp://doi.org/10.1109/NSSMIC.2014.7430844
Indexed BySCI
Language英语
WOS Research AreaNuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000392917500100
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionFaculty of Science and Technology
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Affiliation1.Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong
2.Department of Electrical and Computer Engineering, Univ. of Macau, Macau SAR, China
3.the Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China
4.the Department of Radiology, Johns Hopkins University School of Medicine, and F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
Recommended Citation
GB/T 7714
Jing Yuan,Greta Seng Peng Mok,Qinwei Zhang,et al. Improved Quantification of Chemical Exchange Saturation Transfer (CEST) MRI by Nonlocal Means[C],2014.
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