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Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity
Zhao, Wenwen1,2; Ge, Haixia3; Liu, Kang1; Chen, Xiuping2; Zhang, Jian4; Liu, Baolin1
2017-02
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume83Issue:3-4Pages:203-209
Abstract

Nandinine is a derivative of berberine that has high efficacy for treating cardiovascular diseases. This study investigated the effects of berberine and nandinine on the regulation of insulin sensitivity in adipocytes. Through treatment with macrophage-derived conditioned medium in 3T3-L1 adipocytes, dysregulation of adipokine production and activation of the l kappa B kinase beta/nuclear factor-kappa B pathway was induced. However, these phenomena were effectively reversed by berberine, nandinine, and salicylate pretreatments. Furthermore, both berberine and nandinine inhibited serine phosphorylation of insulin receptor substrate-1 induced by l kappa B kinase beta and increased tyrosine phosphorylation of insulin receptor substrate-1 to activate the PI3K/Akt pathway, which finally led to insulin-mediated glucose uptake. In addition, berberine and nandinine significantly increased AMP-activated protein kinase activity, thereby contributing to their anti-inflammatory effect by inhibiting I kappa B kinase a beta activation. Finally, in vivo studies demonstrated that both berberine (100 or 200mg/kg) and nandinine (100 or 200mg/kg) effectively ameliorated glucose intolerance and induced the insulin sensitivity index in mice. In conclusion, berberine and nandinine attenuated insulin resistance in adipocytes by inhibiting inflammation in an AMP-activated protein kinase-dependent manner. Berberine and nandinine may be used as dietary supplements and nandinine is a new candidate for obesity treatment.

KeywordBerberine Nandinine Insulin Resistance 3t3-l1 Adipocytes Inflammation Ampk
DOIhttp://doi.org/10.1055/s-0042-110576
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000397029700002
PublisherGEORG THIEME VERLAG KG
The Source to ArticleWOS
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLiu, Baolin
Affiliation1.Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, P. R. China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China
3.Department of Pharmacy, Huzhou University, Huzhou, P. R. China
4.State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhao, Wenwen,Ge, Haixia,Liu, Kang,et al. Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity[J]. PLANTA MEDICA,2017,83(3-4):203-209.
APA Zhao, Wenwen,Ge, Haixia,Liu, Kang,Chen, Xiuping,Zhang, Jian,&Liu, Baolin.(2017).Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity.PLANTA MEDICA,83(3-4),203-209.
MLA Zhao, Wenwen,et al."Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity".PLANTA MEDICA 83.3-4(2017):203-209.
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