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Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route
Zhou, Xing1,2; Zhang, Xiangjun1,3; Han, Songling1; Dou, Yin1,2; Liu, Mengyu1,2; Zhang, Lin4; Guo, Jiawei1; Shi, Qing1; Gong, Genghao1; Wang, Ruibing3; Hu, Jiang5; Li, Xiaohui2; Zhang, Jianxiang1,2
2017-02
Source PublicationNANO LETTERS
ISSN1530-6984
Volume17Issue:2Pages:1056-1064
Abstract

Targeting of nanoparticles to distant diseased sites after oral delivery remains highly challenging due to the existence of many biological barriers in the gastrointestinal tract. Here we report targeted oral delivery of diverse nanoparticles in multiple disease models, via a "Trojan horse" strategy based on a bioinspired yeast capsule (YC). Diverse charged nanoprobes including quantum dots (QDs), iron oxide nanoparticles (IONPs), and assembled organic fluorescent nanoparticles can be effectively loaded into YC through electrostatic force-driven spontaneous deposition, resulting in different diagnostic YC assemblies. Also, different positive nano therapies containing an anti-inflammatory drug indomethacin (IND) or an antitumor drug paclitaxel (PTX) are efficiently packaged into YC. YCs containing either nanoprobes or nano therapies may be rapidly endocytosed by macrophages and maintained in cells for a relatively long period of time. Post oral administration, nanoparticles packaged in YC are first transcytosed by M cells and sequentially endocytosed by macrophages, then transported to neighboring lymphoid tissues, and finally delivered to remote diseased sites of inflammation or tumor in mice or rats, all through the natural route of macrophage activation, recruitment, and deployment. For the examined acute inflammation model, the targeting efficiency of YC-delivered QDs or IONPs is even higher than that of control nanoprobes administered at the same dose via intravenous injection. Assembled IND or PTX nanotherapies orally delivered via YCs exhibit remarkably potentiated efficacies as compared to nanotherapies alone in animal models of inflammation and tumor, which is consistent with the targeting effect and enhanced accumulation of drug molecules at diseased sites. Consequently, through the intricate transportation route, nanoprobes or nanotherapies enveloped in YC can be preferentially delivered to desired targets, affording remarkably improved efficacies for the treatment of multiple diseases associated with inflammation.

KeywordYeast Microcapsule Nanoparticle Oral Targeting Drug Delivery Imaging
DOIhttp://doi.org/10.1021/acs.nanolett.6b04523
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000393848800064
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHu, Jiang; Li, Xiaohui; Zhang, Jianxiang
Affiliation1.Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
2.Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
4.Department of Radiation, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
5.Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States
Recommended Citation
GB/T 7714
Zhou, Xing,Zhang, Xiangjun,Han, Songling,et al. Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route[J]. NANO LETTERS,2017,17(2):1056-1064.
APA Zhou, Xing.,Zhang, Xiangjun.,Han, Songling.,Dou, Yin.,Liu, Mengyu.,...&Zhang, Jianxiang.(2017).Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route.NANO LETTERS,17(2),1056-1064.
MLA Zhou, Xing,et al."Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route".NANO LETTERS 17.2(2017):1056-1064.
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