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Longitudinal changes in prospective memory and their clinical correlates at 1-year follow-up in first-episode schizophrenia
Zhou, Fu-Chun1; Wang, Chuan-Yue1; Ungvari, Gabor S.2,3; Ng, Chee H.4; Zhou, Yan1; Zhang, Liang1; Zhou, Jingjing1; Shum, David H. K.5; Man, David6; Liu, Deng-Tang7; Li, Jun8,9,10; Xiang, Yu-Tao11
2017-02-28
Source PublicationPLOS ONE
ISSN1932-6203
Volume12Issue:2
Abstract

This study aimed to investigate prospective memory (PM) and the association with clinical factors at 1-year follow-up in first-episode schizophrenia (FES). Thirty-two FES patients recruited from a university-affiliated psychiatric hospital in Beijing and 17 healthy community controls (HCs) were included. Time-and event-based PM (TBPM and EBPM) performances were measured with the Chinese version of the Cambridge Prospective Memory Test (CCAMPROMPT) at baseline and at one-year follow-up. A number of other neurocognitive tests were also administered. Remission was determined at the endpoint according to the PANSS score <= 3 for selected items. Repeated measures analysis of variance revealed a significant interaction between time (baseline vs. endpoint) and group (FES vs. HCs) for EBPM (F-(1,F- (44)) = 8.8, p = 0.005) and for all neurocognitive components. Paired samples t-tests showed significant improvement in EBPM in FES (13.1 +/- 3.7 vs. 10.3 +/- 4.8; t = 3.065, p = 0.004), compared to HCs (15.7 +/- 3.6 vs. 16.5 +/- 2.3; t = -1.248, p = 0.230). A remission rate of 59.4% was found in the FES group. Analysis of covariance revealed that remitters performed significantly better on EBPM (14.9 +/- 2.6 vs. 10.4 +/- 3.6; F-(1,F- 25) = 12.2, p = 0.002) than non-remitters at study endpoint. The association between EBPM and 12-month clinical improvement in FES suggests that EBPM may be a potential neurocognitive marker for the effectiveness of standard pharmacotherapy. Furthermore, the findings also imply that PM may not be strictly a trait-related endophenotype as indicated in previous studies.

DOIhttps://doi.org/10.1371/journal.pone.0172114
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000395980200011
PublisherPUBLIC LIBRARY SCIENCE
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiang, Yu-Tao
Affiliation1.Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
2.The University of Notre Dame Australia / Marian Centre, Perth, Australia
3.School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia
4.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
5.Menzies Health Institute Queensland and School of Applied Psychology, Griffith University, Gold Coast, Queensland, Australia
6.Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong SAR, China
7.Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
8.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing, China
9.IDG/McGovern Institute for Brain Research, Beijing, China
10.Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China
11.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhou, Fu-Chun,Wang, Chuan-Yue,Ungvari, Gabor S.,et al. Longitudinal changes in prospective memory and their clinical correlates at 1-year follow-up in first-episode schizophrenia[J]. PLOS ONE,2017,12(2).
APA Zhou, Fu-Chun.,Wang, Chuan-Yue.,Ungvari, Gabor S..,Ng, Chee H..,Zhou, Yan.,...&Xiang, Yu-Tao.(2017).Longitudinal changes in prospective memory and their clinical correlates at 1-year follow-up in first-episode schizophrenia.PLOS ONE,12(2).
MLA Zhou, Fu-Chun,et al."Longitudinal changes in prospective memory and their clinical correlates at 1-year follow-up in first-episode schizophrenia".PLOS ONE 12.2(2017).
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