UM
Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials
Chan, Weng-I; Zhang, Guangpan; Li, Xin; Leung, Chung-Hang; Ma, Dik-Lung; Dong, Lei; Wang, Chunming
2017-03
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume5Issue:3Pages:403-407
AbstractPolymers that can activate the immune system may become useful biomaterials tools, given that the mechanisms underlying their actions are well understood. Herein, we report a novel type of interaction between polymers and immune cells - in studying the influence of the three major types of carrageenan (CGN) polysaccharides on monocyte behaviour in vitro, we found only the lambda-type induced monocyte adhesion and this action requires the presence of an adequate amount of serum. Further analyses indicated lambda-CGN bound interleukin-8 (IL-8) in the serum and activated the cultured monocytes through an IL-8-dependent pathway. This is the first demonstration that a polymer, with a renowned immunostimulatory effect, activates the immune system via binding and harnessing the function of a specific cytokine in the microenvironment. This is a new mechanism underlying polymer-immunity interactions that may shed light on future design and application of biomaterials tools targeting the immune system for a wide variety of therapeutic applications.
DOI10.1039/c6bm00799f
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000395886300004
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Chan, Weng-I,Zhang, Guangpan,Li, Xin,et al. Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials[J]. BIOMATERIALS SCIENCE,2017,5(3):403-407.
APA Chan, Weng-I.,Zhang, Guangpan.,Li, Xin.,Leung, Chung-Hang.,Ma, Dik-Lung.,...&Wang, Chunming.(2017).Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials.BIOMATERIALS SCIENCE,5(3),403-407.
MLA Chan, Weng-I,et al."Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials".BIOMATERIALS SCIENCE 5.3(2017):403-407.
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