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Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging
Ke, Chi-Shiang1; Fang, Chia-Chia1; Yan, Jia-Ying2; Tseng, Po-Jung1; Pyle, Joseph R.3; Chen, Chuan-Pin1; Lin, Shu-Yi2; Chen, Jixin3; Zhang, Xuanjun4; Chan, Yang-Hsiang1
2017-03
Source PublicationACS NANO
ISSN1936-0851
Volume11Issue:3Pages:3166-3177
Abstract

This article describes the design and synthesis of donor bridge acceptor-based semiconducting polymer dots (Pdots) that exhibit narrow-band emissions, ultrahigh brightness, and large Stokes shifts in the near-infrared (MR) region. We systematically investigated the effect of pi-bridges on the fluorescence quantum yields of the donor bridge acceptor-based Pdots. The Pdots could be excited by a 488 or 532 nm laser and have a high fluorescence quantum yield of 33% with a Stokes shift of more than 200 nm. The emission full width at half-maximum of the Pdots can be as narrow as 29 nm, about 2.5 times narrower than that of inorganic quantum dots at the same emission wavelength region. The average per-particle brightness of the Pdots is at least 3 times larger than that of the commercially available quantum dots. The excellent biocompatibility of these Pdots was demonstrated in vivo, and their specific cellular labeling capability was also approved by different cell lines. By taking advantage of the durable brightness and remarkable stability of these MR fluorescent Pdots, we performed in vivo microangiography imaging on living zebrafish embryos and long-term tumor monitoring on mice. We anticipate these donor bridge acceptor-based NIR-fluorescent Pdots with narrow-band emissions to find broad use in a variety of multiplexed biological applications.

KeywordSemiconducting Polymer Dots Narrow Fluorescence Near -infrared Emission Pi-bridge Bioimaging
DOI10.1021/acsnano.7b00215
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000398014900082
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:57   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Natl Sun Yat Sen Univ, Dept Chem, 70 Lien Hai Rd, Kaohsiung 80424, Taiwan
2.Natl Hlth Res Inst, Ctr Nanomed Res, 35 Keyan Rd, Zhunan 35053, Taiwan
3.Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA
4.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Ke, Chi-Shiang,Fang, Chia-Chia,Yan, Jia-Ying,et al. Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging[J]. ACS NANO,2017,11(3):3166-3177.
APA Ke, Chi-Shiang.,Fang, Chia-Chia.,Yan, Jia-Ying.,Tseng, Po-Jung.,Pyle, Joseph R..,...&Chan, Yang-Hsiang.(2017).Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging.ACS NANO,11(3),3166-3177.
MLA Ke, Chi-Shiang,et al."Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging".ACS NANO 11.3(2017):3166-3177.
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