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A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips
Dong, Cheng1,2; Jia, Yanwei1; Gao, Jie1; Chen, Tianlan1; Mak, Pui-In1,2; Vai, Mang-I1,2; Martins, Rui P.1,2
2017-03-07
Source PublicationLAB ON A CHIP
ISSN1473-0197
Volume17Issue:5Pages:896-904
Abstract

Existing digital microfluidic (DMF) chips exploit the electrowetting on dielectric (EWOD) force to perform droplet splitting. However, the current splitting methods are not flexible and the volume of the droplets suffers from a large variation. Herein, we propose a DMF chip featuring a 3D microblade structure to enhance the droplet-splitting performance. By exploiting the EWOD force for shaping and manipulating the mother droplet, we obtain an average dividing error of <2% in the volume of the daughter droplets for a number of fluids such as deionized water, DNA solutions and DNA-protein mixtures. Customized droplet splitting ratios of up to 20:80 are achieved by positioning the blade at the appropriate position. Additionally, by fabricating multiple 3D microblades on one electrode, two to five uniform daughter droplets can be generated simultaneously. Finally, by taking synthetic DNA targets and their corresponding molecular beacon probes as a model system, multiple potential pathogens that cause sepsis are detected rapidly on the 3D-blade-equipped DMF chip, rendering it as a promising tool for parallel diagnosis of diseases.

DOI10.1039/c6lc01539e
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
WOS SubjectBiochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology
WOS IDWOS:000395893500013
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF MICROELECTRONICS
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Affiliation1.State-Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Macao, China
2.Faculty of Science and Technology – ECE, University of Macau, Macao, China
First Author AffilicationUniversity of Macau;  Faculty of Science and Technology
Recommended Citation
GB/T 7714
Dong, Cheng,Jia, Yanwei,Gao, Jie,et al. A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips[J]. LAB ON A CHIP,2017,17(5):896-904.
APA Dong, Cheng.,Jia, Yanwei.,Gao, Jie.,Chen, Tianlan.,Mak, Pui-In.,...&Martins, Rui P..(2017).A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips.LAB ON A CHIP,17(5),896-904.
MLA Dong, Cheng,et al."A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips".LAB ON A CHIP 17.5(2017):896-904.
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