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Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells
Liu, Chenfu1; Yang, Chao2; Lu, Lihua1,3; Wang, Wanhe1; Tan, Weihong4,5; Leung, Chung-Hang2; Ma, Dik-Lung1
2017-03-07
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume53Issue:19Pages:2822-2825
Abstract

Two luminescent iridium(III) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium( III) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

DOI10.1039/c6cc08109f
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000396029600005
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorTan, Weihong; Leung, Chung-Hang; Ma, Dik-Lung
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
4.Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, USA
5.Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, Chenfu,Yang, Chao,Lu, Lihua,et al. Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells[J]. CHEMICAL COMMUNICATIONS,2017,53(19):2822-2825.
APA Liu, Chenfu.,Yang, Chao.,Lu, Lihua.,Wang, Wanhe.,Tan, Weihong.,...&Ma, Dik-Lung.(2017).Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells.CHEMICAL COMMUNICATIONS,53(19),2822-2825.
MLA Liu, Chenfu,et al."Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells".CHEMICAL COMMUNICATIONS 53.19(2017):2822-2825.
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