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Fetal bovine serum influences the stability and bioactivity of resveratrol analogues: A polyphenol-protein interaction approach
Tang, Fen1; Xie, Yixi1; Cao, Hui2; Yang, Hua1; Chen, Xiaoqing1; Xiao, Jianbo2,3
2017-03-15
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume219Pages:321-328
Abstract

Fetal bovine serum (FBS) is a universal growth supplement of cell and tissue culture media. Herein, the influences of FBS on the stability and antioxidant activity of 21 resveratrol analogues were investigated using a polyphenol-protein interaction approach. The structure-stability. relationships of resveratrol analogues in FBS showed a clear decrease in the stability of hydroxylated resveratrol analogues in the order: resorcinol-type > pyrogallol-type > catechol-type. The glycosylation and methoxylation of resveratrol analogues enhanced their stability. A linear relationship between the stability of resveratrol analogues in FBS and the affinity of resveratrol analogues-FBS interaction was found. The oxidation process is not the only factor governing the stability of resveratrol analogues in FBS. These results facilitated the insightful investigation of the role of polyphenol-protein interactions in serum, thereby providing some fundamental clues for future clinical research and pharmacological studies on natural small molecules. (C) 2016 Elsevier Ltd. All rights reserved.

KeywordResveratrol Analogues Fetal Bovine Serum Structure-affinity Relationship Free Radical Scavenging Activity Stability
DOI10.1016/j.foodchem.2016.09.154
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000386984100041
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
2.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macau
3.Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany
Recommended Citation
GB/T 7714
Tang, Fen,Xie, Yixi,Cao, Hui,et al. Fetal bovine serum influences the stability and bioactivity of resveratrol analogues: A polyphenol-protein interaction approach[J]. FOOD CHEMISTRY,2017,219:321-328.
APA Tang, Fen,Xie, Yixi,Cao, Hui,Yang, Hua,Chen, Xiaoqing,&Xiao, Jianbo.(2017).Fetal bovine serum influences the stability and bioactivity of resveratrol analogues: A polyphenol-protein interaction approach.FOOD CHEMISTRY,219,321-328.
MLA Tang, Fen,et al."Fetal bovine serum influences the stability and bioactivity of resveratrol analogues: A polyphenol-protein interaction approach".FOOD CHEMISTRY 219(2017):321-328.
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