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In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer
Wei, Ran1; Wong, Janet Pik Ching1; Lyu, Peng1; Xi, Xinping1; Tong, Olivia1; Zhang, Shu-Dong2; Yuen, Hiu Fung3; Shirasawa, Senji4; Kwok, Hang Fai1
2018-09
Source PublicationJOURNAL OF CELLULAR AND MOLECULAR MEDICINE
ISSN1582-4934
Volume22Issue:9Pages:4097-4105
Abstract

Osteopontin (OPN) has been shown to promote colorectal cancer (CRC) progression; however, the mechanism of OPN-induced CRC progression is largely unknown. In this study, we found that OPN overexpression led to enhanced anchorage-independent growth, cell migration and invasion in KRAS gene mutant cells but to a lesser extent in KRAS wild-type cells. OPN overexpression also induced PI3K signalling, expression of Snail and Matrix metallopeptidase 9 (MMP9), and suppressed the expression of E-cadherin in KRAS mutant cells. In human CRC specimens, a high-level expression of OPN significantly predicted poorer survival in CRC patients and OPN expression was positively correlated with MMP9 expression, and negatively correlated with E-cadherin expression. Furthermore, we have found that 15 genes were co-upregulated in OPN highly expression CRC and a list of candidate drugs that may have potential to reverse the secreted phosphoprotein 1 (SPP1) gene signature by connectivity mapping. In summary, OPN is a potential prognostic indicator and therapeutic target for colon cancer.

KeywordColorectal Cancer Connectivity Mapping Osteopontin Survival
DOI10.1111/jcmm.13686
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Research & Experimental Medicine
WOS SubjectCell Biology ; Medicine, Research & Experimental
WOS IDWOS:000442849700008
PublisherWILEY
The Source to ArticleWOS
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKwok, Hang Fai
Affiliation1.Faculty of Health Sciences, University ofMacau, Taipa, Macau
2.Northern Ireland Centre for StratifiedMedicine, Biomedical Sciences ResearchInstitute, University of Ulster, Londonderry,UK
3.Institute of Molecular and Cell Biology,A*STAR, Singapore City, Singapore
4.Department of Cell Biology, Faculty ofMedicine, Fukuoka University, Fukuoka,Japan
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wei, Ran,Wong, Janet Pik Ching,Lyu, Peng,et al. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2018,22(9):4097-4105.
APA Wei, Ran.,Wong, Janet Pik Ching.,Lyu, Peng.,Xi, Xinping.,Tong, Olivia.,...&Kwok, Hang Fai.(2018).In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,22(9),4097-4105.
MLA Wei, Ran,et al."In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22.9(2018):4097-4105.
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