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Neural Activation during Anticipation of Near Pain-Threshold Stimulation among the Pain-Fearful
Zhou Yang1,2; Todd Jackson1,3; Chengzhi Huang2
2016-07-20
Source PublicationFrontiers in Neuroscience
ISSN1662-453X
Volume10Issue:342
Abstract

Fear of pain (FOP) can increase risk for chronic pain and disability but little is known about corresponding neural responses in anticipation of potential pain. In this study, more (10 women, 6 men) and less (7 women, 6 men) pain-fearful groups underwent whole-brain functional magnetic resonance imaging (fMRI) during anticipation of near pain-threshold stimulation. Groups did not differ in the proportion of stimuli judged to be painful but pain-fearful participants reported significantly more state fear prior to stimulus exposure. Within the entire sample, stronger activation was found in several pain perception regions (e.g., bilateral insula, midcingulate cortex (MCC), thalamus, superior frontal gyrus) and visual areas linked to decoding stimulus valences (inferior orbital cortex) during anticipation of "painful" stimuli. Between groups and correlation analyses indicated pain-fearful participants experienced comparatively more activity in regions implicated in evaluating potential threats and processing negative emotions during anticipation (i.e., MCC, mid occipital cortex, superior temporal pole), though group differences were not apparent in most so-called "pain matrix" regions. In sum, trait- and task-based FOP is associated with enhanced responsiveness in regions involved in threat processing and negative affect during anticipation of potentially painful stimulation.

KeywordFear Of Pain Functional Neuroimaging Midcingulate Cortex Pain Anticipation Pain Intensity
DOIhttps://doi.org/10.3389/fnins.2016.00342
URLView the original
Indexed BySSCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000379995900001
PublisherFRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
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Document TypeJournal article
CollectionDEPARTMENT OF PSYCHOLOGY
Corresponding AuthorTodd Jackson
Affiliation1.Key Laboratory of Cognition and Personality, China Education Ministry, Faculty of Psychology, Southwest University, Chongqing, China
2.Department of Chemistry, Southwest University, Chongqing, China
3.Department of Psychology, University of Macau, Macau, China
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhou Yang,Todd Jackson,Chengzhi Huang. Neural Activation during Anticipation of Near Pain-Threshold Stimulation among the Pain-Fearful[J]. Frontiers in Neuroscience,2016,10(342).
APA Zhou Yang,Todd Jackson,&Chengzhi Huang.(2016).Neural Activation during Anticipation of Near Pain-Threshold Stimulation among the Pain-Fearful.Frontiers in Neuroscience,10(342).
MLA Zhou Yang,et al."Neural Activation during Anticipation of Near Pain-Threshold Stimulation among the Pain-Fearful".Frontiers in Neuroscience 10.342(2016).
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