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Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro
Zhong, Zhang-Feng1; Tan, Wen2; Tian, Ke3,4; Yu, Hua1; Qiang, Wen-An4; Wang, Yi-Tao1
2017-04
Source PublicationONCOLOGY REPORTS
ISSN1021-335X
Volume37Issue:4Pages:2016-2024
Abstract

Furanodiene is one of the major bioactive components isolated from the natural product of the plant, Curcuma wenyujin Y.H. Chen et C. Ling. Furanodiene has been found to exert anticancer effects in various types of cancer cell lines, as well as exhibit antimetastatic activities. However, the antimetastatic capacity of furanodiene in combination with the common chemotherapy drug doxorubicin has not been investigated. We found that doxorubicin at a non-toxic concentration induced cell migration and cell invasion in highly metastatic breast cancer cells. Combinational treatments with furanodiene and doxorubicin blocked the invasion and migration of MDA-MB-231 breast cancer cells in vitro. We also clarified the effects of the combination on the signaling pathways involved in migration, invasion, and cytoskeletal organization. When combined with doxorubicin, furanodiene downregulated the expression of integrin alpha V and beta-catenin and inhibited the phosphorylation of paxillin, Src, focal adhesion kinase (FAK), p85, and Akt. Moreover, combinational treatments also resulted in a decrease in matrix metalloproteinase-9 (MMP-9). Further study demonstrated that the co-treatments with furanodiene did not significantly alter the effects of doxorubicin on the tubulin cytoskeleton, represented by no influence on the expression levels of RhoA, Cdc42, N-WASP, and alpha/beta tubulin. These observations indicate that furanodiene is a potential agent that may be utilized to improve the anticancer efficacy of doxorubicin and overcome the risk of chemotherapy in highly metastatic breast cancer.

KeywordFuranodiene Doxorubicin Combination Treatment Breast Cancer Migration Invasion
DOIhttp://doi.org/10.3892/or.2017.5435
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000398138900011
PublisherSPANDIDOS PUBL LTD
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Yi-Tao
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR 999078
2.School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000
3.School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, P.R. China
4.Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhong, Zhang-Feng,Tan, Wen,Tian, Ke,et al. Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro[J]. ONCOLOGY REPORTS,2017,37(4):2016-2024.
APA Zhong, Zhang-Feng,Tan, Wen,Tian, Ke,Yu, Hua,Qiang, Wen-An,&Wang, Yi-Tao.(2017).Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro.ONCOLOGY REPORTS,37(4),2016-2024.
MLA Zhong, Zhang-Feng,et al."Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro".ONCOLOGY REPORTS 37.4(2017):2016-2024.
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