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Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution
Bi, Chao1,2; Miao, Xiao Qing1,3; Chow, Sing Fung4; Wu, Wen Jin1; Yan, Ru1; Liao, Y. H.5; Chow, Albert Hee-Lum4; Zheng, Ying1
2017-04
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
Volume13Issue:3Pages:943-953
Abstract

This study aimed to investigate the particle size effect on bioactivity, cellular internalization and bioavailability of curcumin (CUR) nanosuspension (CUR-NS). CUR-NSs of different particle sizes were prepared by two different anti-solvent precipitation methods. CUR-NS with the smallest size showed similar in vitro anticancer activity and bioavailability to the CUR solution, whereas nanosuspensions of larger particle sizes displayed higher in vitro cellular internalization and cytotoxicity, as well as higher in vivo AUC and slower clearance rate after i. v. administration in rats. CUR solution and different sized CUR-NSs reached the highest concentrations in the lung, followed by liver and spleen while the lowest concentration was observed in the brain after i. v. administration in mice. Specifically, CUR-NS of 70 nm accumulated more in the brain, whereas CUR-NS of 200 nm accrued more in liver and spleen. CUR-NS of 20 nm displayed no significant biodistribution difference compared with CUR solution in all tissues. (C) 2016 Elsevier Inc. All rights reserved.

KeywordCurcumin Nanosuspensions Particle Size Multi-inlet Vortex Mixer Anticancer Activity Pharmacokinetics Biodistribution
DOI10.1016/j.nano.2016.11.004
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000401089100017
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, SAR, China
2.Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
3.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, China
4.School of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, SAR, China
5.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bi, Chao,Miao, Xiao Qing,Chow, Sing Fung,et al. Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(3):943-953.
APA Bi, Chao.,Miao, Xiao Qing.,Chow, Sing Fung.,Wu, Wen Jin.,Yan, Ru.,...&Zheng, Ying.(2017).Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(3),943-953.
MLA Bi, Chao,et al."Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.3(2017):943-953.
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