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Identification of TWIST-interacting genes in prostate cancer
Lyu, Peng1; Zhang, Shu-Dong2; Yuen, Hiu-Fung3; McCrudden, Cian M.4; Wen, Qing5; Chan, Kwok-Wah6; Kwok, Hang Fai1

Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen (PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers. We have investigated two largest prostate cancer patient cohorts available in GEO database and found that TWIST expression is positive correlated with Gleason score and associated with poorer survival. By using a prostate cancer cohort and a prostate cancer cell line dataset, we have identified three potential downstream targets of TWIST, PPM1A, SRP72 and TBCB. TWIST's prognostic capacity is lost when the gene is mutated. Further investigation in the prostate cancer cohort revealed that gene expression of SERPINA, STX7, PDIA2, FMP5, GP1BB, VGLL4, KCNMA1, SHMT2, SAA4 and DIDO1 influence the prognostic significance of TWIST and vice versa. Importantly, eight out of these ten genes are prognostic indicator by itself. In conclusion, our study has further confirmed that TWIST is a prognostic marker in prostate cancer, identified its potential downstream targets and genes that could possibly give additional prognostic value to predict TWIST-mediated prostate cancer progression.

KeywordProstate Cancer Twist Prognostic Marker
URLView the original
Indexed BySCI
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000401068300006
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKwok, Hang Fai
Affiliation1.Faculty of Health Sciences, University of Macau, Avenida de Universidade, Macau 999078, China
2.Northern Ireland Centre for Stratified Medicine, C-TRIC Building, Altnagelvin Hospital Campus, Ulster University, Londonderry BT47 6SB, UK
3.Institute of Molecular and Cellular Biology, Agency for Science, Technology and Reseach, Singapore 138673, Singapore
4.School of Pharmacy, Queen’s University of Belfast, Belfast BT9 7BL, UK
5.Centre for Cancer Research & Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7BL, UK
6.Department of Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong 999077, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Lyu, Peng,Zhang, Shu-Dong,Yuen, Hiu-Fung,et al. Identification of TWIST-interacting genes in prostate cancer[J]. SCIENCE CHINA-LIFE SCIENCES,2017,60(4):386-396.
APA Lyu, Peng.,Zhang, Shu-Dong.,Yuen, Hiu-Fung.,McCrudden, Cian M..,Wen, Qing.,...&Kwok, Hang Fai.(2017).Identification of TWIST-interacting genes in prostate cancer.SCIENCE CHINA-LIFE SCIENCES,60(4),386-396.
MLA Lyu, Peng,et al."Identification of TWIST-interacting genes in prostate cancer".SCIENCE CHINA-LIFE SCIENCES 60.4(2017):386-396.
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