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The Role of endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression
Zhang, Qingyu1; Madden, Nadine Ellen1; Wong, Alice Sze Tsai2; Chow, Billy Kwok Chong2; Lee, Leo Tsz On1
2017-04-07
Source PublicationFRONTIERS IN ENDOCRINOLOGY
ISSN1664-2392
Volume8
Abstract

Ovarian cancer is the seventh most common cancer in women and the most lethal gynecological cancer, causing over 151,000 deaths worldwide each year. Dysregulated production of endocrine hormones, known to have pluripotent effects on cell function through the activation of receptor signaling pathways, is believed to be a high-risk factor for ovarian cancer. An increasing body of evidence suggests that endocrine Gprotein-coupled receptors (GPCRs) are involved in the progression and metastasis of ovarian neoplasms. GPCRs are attractive drug targets because their activities are regulated by more than 25% of all drugs approved by the Food and Drug Administration. Therefore, understanding the role of endocrine GPCRs during ovarian cancer progression and metastasis will allow for the development of novel strategies to design effective chemotherapeutic drugs against malignant ovarian tumors. In this review, we address the signaling pathways and functional roles of several key endocrine GPCRs that are related to the cause, progression, and metastasis of ovarian cancer.

Keywordg Protein-coupled Receptor Ovarian Cancer Endocrine System Peptide Hormone Cell Signaling
DOI10.3389/fendo.2017.00066
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000398413800001
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau
2.School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhang, Qingyu,Madden, Nadine Ellen,Wong, Alice Sze Tsai,et al. The Role of endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression[J]. FRONTIERS IN ENDOCRINOLOGY,2017,8.
APA Zhang, Qingyu,Madden, Nadine Ellen,Wong, Alice Sze Tsai,Chow, Billy Kwok Chong,&Lee, Leo Tsz On.(2017).The Role of endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression.FRONTIERS IN ENDOCRINOLOGY,8.
MLA Zhang, Qingyu,et al."The Role of endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression".FRONTIERS IN ENDOCRINOLOGY 8(2017).
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