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Near-infrared light activation of quenched liposomal Ce6 for synergistic cancer phototherapy with effective skin protection
Feng, Liangzhu1; Tao, Danlei2; Dong, Ziliang2; Chen, Qian2; Chao, Yu2; Liu, Zhuang2; Chen, Meiwan1
2017-05
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume127Pages:13-24
Abstract

Current photodynamic therapy (PDT) is suffering from limited efficacy towards hypoxia tumors and severe post-treatment photo-toxicity such as light-induced skin damages. To make PDT more effective in cancer treatment while being patient-comfortable, herein, a hexylamine conjugated chlorin e6 (hCe6) as the photosensitizer together with a lipophilic near-infrared (NIR) dye 1,1'-dioctadecyl-3,3,3',3'-tetra-methylindotricarbocyanine iodide (DiR) are co-encapsulated into polyethylene glycol (PEG) shelled liposomes. In the obtained DiR-hCe6-liposome, the photosensitizing effect of hCe6 is quenched by DiR via fluorescence resonance energy transfer (FRET). Interestingly, upon irradiation with a 785-nm NIR laser to photobleach DiR, both fluorescence and photodynamic effect of hCe6 in DiR-hCe6-liposome would be activated. Meanwhile, such NIR irradiation applied on tumors of mice with intravenous injection of DiR-hCe6-liposome could result in mild photothermal heating, which in turn would promote intra-tumor blood flow and relieve tumor hypoxia, contributing to the enhanced photodynamic tumor treatment. Importantly, compared to hCe6-loaded liposomes, DiR-hCe6-liposome without being activated by the 785-nm laser shows much lower skin photo-toxicity, demonstrating its great skin protection effect. This work demonstrates a promising yet simple strategy to prepare NIR-light-activatable photodynamic theranostics for synergistic cancer phototherapy, which is featured high specificity/efficacy in tumor treatment with minimal photo-toxicity towards the skin. (C) 2016 Published by Elsevier Ltd.

KeywordNir Light Activatable Pdt Tumor Reoxygenation Synergistic Cancer Phototherapy Skin Protection
DOI10.1016/j.biomaterials.2016.11.027
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000398872300002
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
2.Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Feng, Liangzhu,Tao, Danlei,Dong, Ziliang,et al. Near-infrared light activation of quenched liposomal Ce6 for synergistic cancer phototherapy with effective skin protection[J]. BIOMATERIALS,2017,127:13-24.
APA Feng, Liangzhu.,Tao, Danlei.,Dong, Ziliang.,Chen, Qian.,Chao, Yu.,...&Chen, Meiwan.(2017).Near-infrared light activation of quenched liposomal Ce6 for synergistic cancer phototherapy with effective skin protection.BIOMATERIALS,127,13-24.
MLA Feng, Liangzhu,et al."Near-infrared light activation of quenched liposomal Ce6 for synergistic cancer phototherapy with effective skin protection".BIOMATERIALS 127(2017):13-24.
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