UM
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway
Yu, Jie; Zheng, Jiacheng; Lin, Jiajia; Jin, Linlu; Yu, Rui; Mak, Shinghung; Hu, Shengquan; Sun, Hongya; Wu, Xiang; Zhang, Zaijun; Lee, Mingyuen; Tsim, Wahkeung; Su, Wei; Zhou, Wenhua; Cui, Wei; Han, Yifan; Wang, Qinwen
2017-05
Source PublicationCELLULAR AND MOLECULAR NEUROBIOLOGY
ISSN0272-4340
Volume37Issue:4Pages:655-664
AbstractOxidative stress-induced neuronal apoptosis plays an important role in many neurodegenerative disorders. In this study, we have shown that indirubin-3-oxime, a derivative of indirubin originally designed for leukemia therapy, could prevent hydrogen peroxide (H2O2)-induced apoptosis in both SH-SY5Y cells and primary cerebellar granule neurons. H2O2 exposure led to the increased activities of glycogen synthase kinase 3 beta (GSK3 beta) and extracellular signal-regulated kinase (ERK) in SH-SY5Y cells. Indirubin-3-oxime treatment significantly reversed the altered activity of both the PI3-K/Akt/GSK3 beta cascade and the ERK pathway induced by H2O2. In addition, both GSK3 beta and mitogen-activated protein kinase inhibitors significantly prevented H2O2-induced neuronal apoptosis. Moreover, specific inhibitors of the phosphoinositide 3-kinase (PI3-K) abolished the neuroprotective effects of indirubin-3-oxime against H2O2-induced neuronal apoptosis. These results strongly suggest that indirubin-3-oxime prevents H2O2-induced apoptosis via concurrent inhibiting GSK3 beta and the ERK pathway in SH-SY5Y cells, providing support for the use of indirubin-3-oxime to treat neurodegenerative disorders caused or exacerbated by oxidative stress.
KeywordIndirubin-3-oxime H2O2 GSK3 beta PI3-K ERK
DOI10.1007/s10571-016-0402-z
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Neurosciences & Neurology
WOS SubjectCell Biology ; Neurosciences
WOS IDWOS:000399013600008
PublisherSPRINGER/PLENUM PUBLISHERS
The Source to ArticleWOS
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Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Yu, Jie,Zheng, Jiacheng,Lin, Jiajia,et al. Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2017,37(4):655-664.
APA Yu, Jie.,Zheng, Jiacheng.,Lin, Jiajia.,Jin, Linlu.,Yu, Rui.,...&Wang, Qinwen.(2017).Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway.CELLULAR AND MOLECULAR NEUROBIOLOGY,37(4),655-664.
MLA Yu, Jie,et al."Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway".CELLULAR AND MOLECULAR NEUROBIOLOGY 37.4(2017):655-664.
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