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Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa
Wu, Jie-Wei; Tang, Chun-Ping; Cai, Yao-Yao; Ke, Chang-Qiang; Lin, Li-Gen; Yao, Sheng; Ye, Yang
2017-05
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume28Issue:5Pages:927-930
AbstractPhytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones, ineupatolides D and E (1 and 2), together with three known analogs. The structures of the new compounds were established by extensive analysis of 1D and 2D NMR spectra, as well as MS data. Their absolute configurations were determined by CD spectra. All compounds showed moderate inhibitory effects on A431, A549, BGC-823, HL-60, HT-29, and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 mu M. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
KeywordInula cappa Germacrane Sesquiterpene lactones Ineupatolide D Ineupatolide E
DOI10.1016/j.cclet.2016.11.011
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000402444600001
PublisherELSEVIER SCIENCE INC
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Wu, Jie-Wei,Tang, Chun-Ping,Cai, Yao-Yao,et al. Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa[J]. CHINESE CHEMICAL LETTERS,2017,28(5):927-930.
APA Wu, Jie-Wei.,Tang, Chun-Ping.,Cai, Yao-Yao.,Ke, Chang-Qiang.,Lin, Li-Gen.,...&Ye, Yang.(2017).Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa.CHINESE CHEMICAL LETTERS,28(5),927-930.
MLA Wu, Jie-Wei,et al."Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa".CHINESE CHEMICAL LETTERS 28.5(2017):927-930.
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