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Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling
Shreyas Lingadahalli1; Sudhir Jadhao1; Ying Ying Sung2; Mi Chen1; Lingling Hu1; Xin Chen1; Edwin Cheung1
2018
Source PublicationMolecular Cancer Research Search
ISSN1476-4598
Volume16Issue:12Pages:1865-1878
Abstract

The human genome is mostly transcribed, yielding a rich repository of noncoding transcripts that are involved in a myriad of biological processes including cancer. However, how many noncoding transcripts such as long noncoding RNAs (lncRNA) function in cancer is still unclear. This study identified a novel set of clinically relevant androgen-regulated lncRNAs in prostate cancer. Among this group, LINC00844 was demonstrated to be a direct androgen-regulated target that is actively transcribed in androgen receptor (AR)–dependent prostate cancer cells. The expression of LINC00844 is higher in normal prostate compared with malignant and metastatic prostate cancer clinical specimens, and patients with low expression had a poor prognosis and significantly increased biochemical recurrence, suggesting LINC00844 functions in suppressing tumor progression and metastasis. Indeed, in vitro loss-of-function studies revealed that LINC00844prevents prostate cancer cell migration and invasion. Moreover, findings from gene expression profiling analysis indicated that LINC00844 functions in trans, affecting global androgen-regulated gene transcription. Mechanistic evidence reveals that LINC00844 is important in facilitating AR binding to the chromatin. Finally, LINC00844 mediates its phenotypic effects in part by activating the expression of NDRG1, a crucial cancer metastasis suppressor. Collectively, LINC00844is a novel coregulator of AR that plays a central role in the androgen transcriptional network and the development and progression of prostate cancer.

DOI10.1158/1541-7786.MCR-18-0087
Indexed By其他
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau.
2.Genome Institute of Singapore, Singapore, Singapore.
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Shreyas Lingadahalli,Sudhir Jadhao,Ying Ying Sung,et al. Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling[J]. Molecular Cancer Research Search,2018,16(12):1865-1878.
APA Shreyas Lingadahalli.,Sudhir Jadhao.,Ying Ying Sung.,Mi Chen.,Lingling Hu.,...&Edwin Cheung.(2018).Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling.Molecular Cancer Research Search,16(12),1865-1878.
MLA Shreyas Lingadahalli,et al."Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling".Molecular Cancer Research Search 16.12(2018):1865-1878.
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