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TNFR2-expressing CD4(+) Foxp3(+) regulatory T cells in cancer immunology and immunotherapy
Jiang He1,2; Ruixin Li1; Yibo Chen1; Yuanjia Hu1; Xin Chen1
Source PublicationCancer Immunotherapy

CD4+ Foxp3+ regulatory T cells (Tregs) represent a major cellular mechanism in tumor immune evasion. Elimination of Treg activity has become a strategy to devise an effective tumor immunotherapy. We reported that TNF receptor type II (TNFR2), one of two receptors transducing TNF biological activity, is preferentially expressed by the most suppressive subset of Tregs. By interaction with TNFR2, TNF plays a decisive role in the activation, expansion and phenotype stability of Tregs. We also found that highly suppressive TNFR2-expressing Tregs appear to be tumor-associated Tregs. This finding has been supported by recent studies in mouse tumor models and in cancer patients. In this chapter, published data revealing the important role of TNFR2+ Tregs in tumor development and metastasis in different tumor types are reviewed and analyzed. The therapeutic potential of targeting TNF-TNFR2 interaction as means to eliminate Treg activity, and consequently to enhance anti-tumor immune responses, also is discussed.

KeywordRegulatory t Cells Immunotherapy Cancer Tumor Necrosis Factor Receptor Type 2 Tumor Necrosis Factor
WOS IDWOS:000486236000005
WOS KeywordBiochemistry & Molecular Biology ; Oncology ; Immunology
WOS Research AreaBiochemistry & Molecular Biology ; Oncology ; Immunology
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Document TypeBook chapter
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXin Chen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Investment Banking, Shenzhen Rhino Star Information Co. Ltd., Shenzhen
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Jiang He,Ruixin Li,Yibo Chen,et al. TNFR2-expressing CD4(+) Foxp3(+) regulatory T cells in cancer immunology and immunotherapy:Elsevier,2019:101-117.
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