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Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells
Zou, HM; He, TZ; Chen, X
2019
Source PublicationINTERNATIONAL IMMUNOPHARMACOLOGY
ISSN1567-5769
Volume69Pages:307-312
Abstract

Tetrandrine (TET) is an anti-inflammatory compound isolated from Chinese herb Stephania teirandra S. Moore. It was reported recently that the differentiation of Th17 cells was inhibited, while the generation of induced Treg cells (iTregs) was promoted, by TET treatment. We therefore carefully examined the effect of TET on the differentiation of four major subsets of T helper cells. The results showed that in vitro treatment with TET potently inhibited the differentiation of Th1, Th2 and Th17 cells. Administration of LPS resulted in a mixed Th1, Th2 and Th17 responses in normal mice, and such effect of LPS was inhibited by in vivo TET treatment as well. In contrast, TET did not promote or inhibit the in vitro generation of iTregs from nave CD4 (+)CD25 (-)Foxp3/gfp(-) T cells. Furthermore, spontaneous and rapamycin-induced conversion of nave CD4(+)CD25(-)Foxp3/gfp(-) T cells into Foxp3-expressing iTregs in congenic mice was not affected by TET treatment. Thus, TET had the capacity to inhibit the differentiation of proinflammatory Th1, Th2 and Th17 cells, while sparing the generation of Tregs. As a Treg-friendly and broad spectrum anti-inflammatory agent, the molecular mechanism and the therapeutic potential of TET in various human inflammatory diseases should be further studied.

KeywordTetrandrine Itreg Cells Th17 Cells Th2 Cells Th1 Cells
DOI10.1016/j.intimp.2019.01.040
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Pharmacology & Pharmacy
WOS SubjectImmunology ; Pharmacology & Pharmacy
WOS IDWOS:000463125200036
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Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniv Macau, Bldg N22,Rm 7032, Macau, Peoples R China.
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zou, HM,He, TZ,Chen, X. Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2019,69:307-312.
APA Zou, HM,He, TZ,&Chen, X.(2019).Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells.INTERNATIONAL IMMUNOPHARMACOLOGY,69,307-312.
MLA Zou, HM,et al."Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells".INTERNATIONAL IMMUNOPHARMACOLOGY 69(2019):307-312.
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