UM  > 中華醫藥研究院
Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel
Sun, Lin1; Liu, Zeyu1; Wang, Lun1; Cun, Dongmei2; Tong, Henry H. Y.3; Yan, Ru1; Chen, Xin1; Wang, Ruibing1; Zheng, Ying1
2017-05-28
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume254Pages:44-54
Abstract

Psoriasis is an immune-mediated skin disorder, which is triggered by the aberrant activation of dendritic cells in skin. This activation is followed by the complex interaction between the immune cells in the skin and keratinocyte in the epidermis. To improve the conditions of poor aqueous solubility and chemical stability, overcome skin barriers, and enhance in vivo anti-psoriatic activity, curcumin (Cur) loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were fabricated and administered by topical route to treat imiquimod (IMQ)induced psoriasis-like mouse model. Spherical Cur-NPs with the mean particle sizes of 50 nm and 150 nm, respectively, were fabricated using a multi-inlet vortex mixer system, with both exhibiting significantly stronger anti-proliferation effect than Cur solution on HaCaT cells in vitro. Psoriatic skin was utilized in the in vitro skin penetration studies, and the results demonstrated that more drugs penetrated through or accumulated in the skin when administered as the Cur-NPs-loaded hydrogel compared to the drug suspension loaded hydrogel. To compare the nanosizing effect of these Cur-NPs, the mice with IMQ-induced psoriasis-like skin disease were treated with blank gel, Cur gel, 50 nm sized NPs gel, 150 nm sized NPs gel or tracrolimus cream (positive control), respectively. The results indicated that Cur-NPs hydrogel has a superior performance to Cur hydrogel on the IMQ-induced psoriasis-like mouse model in terms of morphological evaluation, biomarkers at mRNA, and protein levels. In conclusion, encapsulation of Cur into PLGA NPs, particularly for NPs of 50 nm, could facilitate lipophilic Cur's dispersion, sustained-release, accumulation, and penetration across the skin and into the blood circulation, which significantly improves anti-psoriasis activity in mice.

KeywordCurcumin Plga Nanoparticle Penetration Psoriasis-like Mouse Model Topical Drug Delivery
DOIhttp://doi.org/10.1016/j.jconrel.2017.03.385
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000403056700005
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:33   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZheng, Ying
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2.Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, Liaoning, China.
3.School of Health Sciences, Macao Polytechnic Institute, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Sun, Lin,Liu, Zeyu,Wang, Lun,et al. Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel[J]. JOURNAL OF CONTROLLED RELEASE,2017,254:44-54.
APA Sun, Lin.,Liu, Zeyu.,Wang, Lun.,Cun, Dongmei.,Tong, Henry H. Y..,...&Zheng, Ying.(2017).Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel.JOURNAL OF CONTROLLED RELEASE,254,44-54.
MLA Sun, Lin,et al."Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel".JOURNAL OF CONTROLLED RELEASE 254(2017):44-54.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, Lin]'s Articles
[Liu, Zeyu]'s Articles
[Wang, Lun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, Lin]'s Articles
[Liu, Zeyu]'s Articles
[Wang, Lun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, Lin]'s Articles
[Liu, Zeyu]'s Articles
[Wang, Lun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.