UM
Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance
Ma, Xiaojun; Lin, Ligen; Yue, Jing; Wu, Chia-Shan; Guo, Cathy A.; Wang, Ruitao; Yu, Kai-Jiang; Devaraj, Sridevi; Murano, Peter; Chen, Zheng; Sun, Yuxiang
2017-06
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume18Issue:6
AbstractHigh fructose corn syrup (HFCS) is widely used as sweetener in processed foods and soft drinks in the United States, largely substituting sucrose (SUC). The orexigenic hormone ghrelin promotes obesity and insulin resistance; ghrelin responds differently to HFCS and SUC ingestion. Here we investigated the roles of ghrelin in HFCS- and SUC-induced adiposity and insulin resistance. To mimic soft drinks, 10-week-old male wild-type (WT) and ghrelin knockout (Ghrelin(-/-)) mice were subjected to ad lib. regular chow diet supplemented with either water (RD), 8% HFCS (HFCS), or 10% sucrose (SUC). We found that SUC-feeding induced more robust increases in body weight and body fat than HFCS-feeding. Comparing to SUC-fed mice, HFCS-fed mice showed lower body weight but higher circulating glucose and insulin levels. Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions.
Keywordghrelin HFCS sucrose fructose glucose adiposity insulin resistance adipose tissue inflammation
DOI10.3390/ijms18061302
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000404581500199
PublisherMDPI AG
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Ma, Xiaojun,Lin, Ligen,Yue, Jing,et al. Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(6).
APA Ma, Xiaojun.,Lin, Ligen.,Yue, Jing.,Wu, Chia-Shan.,Guo, Cathy A..,...&Sun, Yuxiang.(2017).Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(6).
MLA Ma, Xiaojun,et al."Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.6(2017).
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