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Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3
Liu, Jing-Xin1; Shen, Sheng-Nan1; Tong, Qiang2; Wang, Yi-Tao1; Lin, Li-Gen1
2018-09-05
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
Volume834Pages:176-187
Abstract

Oxidative stress contributes to the initiation and progression of liver damage. SIRT3 is a member of nicotinamide adenine dinucleotide-dependent deacetylases that plays a key role in anti-oxidative defense and mitochondrial function in the liver. Honokiol is a natural lignan from the plants of Magnolia genus that exhibits potent anti-oxidative property. This study aims to evaluate the hepatoprotective potential of honokiol against oxidative injury in tert-butyl hydroperoxide (t-BHP)-injured AML12 hepatocytes in vitro and carbon tetrachloride (CCl4)-stimulated liver damaged mice in vivo and to determine whether or not this effect occurs by activating SIRT3. The results showed honokiol protects t-BHP-injured AML12 hepatocytes and CCl4-stimulated liver damage in mice by activating SIRT3. Honokiol reduces the acetylation level of superoxide dismutase 2 to enhance its anti-oxidative capacity, which decreases reactive oxygen species accumulation in AML12 cells. Honokiol increases the deacetylated peroxisome proliferator-activated receptor gamma coactivator 1-alpha level to promote mitochondrial biogenesis. Moreover, honokiol attenuates t-BHP induced mitochondrial fragmentation through Ku70-dynamin-related protein 1 axis. These results suggest that honokiol can ameliorate oxidative damage in hepatocytes by activating SIRT3, which might be a potential therapeutic agent for liver oxidative injury.

KeywordHonokiol Oxidative Stress Liver Sirt3 Mitochondria Fragmentation
DOIhttp://doi.org/10.1016/j.ejphar.2018.07.036
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000440974700021
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin, Li-Gen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau, China
2.Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, Jing-Xin,Shen, Sheng-Nan,Tong, Qiang,et al. Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2018,834:176-187.
APA Liu, Jing-Xin,Shen, Sheng-Nan,Tong, Qiang,Wang, Yi-Tao,&Lin, Li-Gen.(2018).Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3.EUROPEAN JOURNAL OF PHARMACOLOGY,834,176-187.
MLA Liu, Jing-Xin,et al."Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3".EUROPEAN JOURNAL OF PHARMACOLOGY 834(2018):176-187.
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