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Behavioral methods for the functional assessment of hair cells in zebrafish
Yang, Qin; Sun, Peng; Chen, Shi; Li, Hongzhe; Chen, Fangyi
2017-06
Source PublicationFRONTIERS OF MEDICINE
ISSN2095-0217
Volume11Issue:2Pages:178-190
AbstractZebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.
Keywordzebrafish (Danio rerio) behavior auditory startle response vestibular-ocular reflex rheotaxis
DOI10.1007/s11684-017-0507-x
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:000402764400003
PublisherSPRINGER
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Yang, Qin,Sun, Peng,Chen, Shi,et al. Behavioral methods for the functional assessment of hair cells in zebrafish[J]. FRONTIERS OF MEDICINE,2017,11(2):178-190.
APA Yang, Qin,Sun, Peng,Chen, Shi,Li, Hongzhe,&Chen, Fangyi.(2017).Behavioral methods for the functional assessment of hair cells in zebrafish.FRONTIERS OF MEDICINE,11(2),178-190.
MLA Yang, Qin,et al."Behavioral methods for the functional assessment of hair cells in zebrafish".FRONTIERS OF MEDICINE 11.2(2017):178-190.
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