UM
Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy
Zhang, Xiaohan; Li, Qiu; Sun, Xiaodong; Zhang, Baolei; Kang, Hongxiang; Zhang, Fuli; Jin, Yiguang
2017-06
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume3Issue:6Pages:1008-1016
AbstractPhotodynamic therapy (PDT) is an emerging method for the treatment of cancer. Combination of PDT and chemotherapy is a hot topic though the two therapies could not simultaneously exert their perfect effect in vivo. Here we report a doxorubicin-loaded photosensitizer-core pH-responsive copolymer nanocarrier with high tumor targeting and anticancer effects due to integration of PDT with chemotherapy. The pH-responsive photosensitizer-core four-armed star-shaped copolymer, [methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(epsilon-caprolactone)](4)-zinc beta-tetra-(4-carboxyl benzyloxyl)phthalocyanine (PDCZP), was prepared, which was a molecular spherical nanocarrier in aqueous media. The carriers changed from small at high pH to large at low pH (51, 105, and 342 nm at pH 7.4, 6.5, and 5.0, respectively) and the zeta potential gradually increased (7.15, 16.2, and 26.1 mV at the above pH, respectively). PDCZP had a longer emission wavelength (max. 677 nm) than the parent photosensitizer, favoring light penetration through biological tissues. The singlet oxygen (O-1(2)) quantum yield of PDCZP was 0.41. Doxorubicin (DOX) showed rapid release from PDCZP in the acidic media. More importantly, the drug-loaded nanocarriers showed the better in vitro and in vivo anticancer effects under lighting on MCF-7, SW480 cells and HepG2 cells and the murine hepatocellular carcinoma H-22 models than the other groups. PDCZP showed a high tumor targeting effect based on the enhanced permeation and retention effect and its small size. The photosensitizer-core nanocarrier is a promising photodynamic nanocarrier for integrating other therapies.
Keyworddoxorubicin pH-responsive photodynamic therapy phthalocyanine photosensitizer tumor targeting
DOI10.1021/acsbiomaterials.6b00762
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000403386500016
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, Xiaohan,Li, Qiu,Sun, Xiaodong,et al. Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2017,3(6):1008-1016.
APA Zhang, Xiaohan.,Li, Qiu.,Sun, Xiaodong.,Zhang, Baolei.,Kang, Hongxiang.,...&Jin, Yiguang.(2017).Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy.ACS BIOMATERIALS SCIENCE & ENGINEERING,3(6),1008-1016.
MLA Zhang, Xiaohan,et al."Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy".ACS BIOMATERIALS SCIENCE & ENGINEERING 3.6(2017):1008-1016.
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