Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma

doi:10.1186/s12885-017-3399-x

	Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma
	Yip, Chi Wai; Lam, Ching Yan; Poon, Terence C. W.; Cheung, Tan To; Cheung, Phyllis F. Y.; Fung, Sze Wai; Wang, Xiao Qi; Leung, Idy C. Y.; Ng, Linda W. C.; Lo, Chung Mau; Tsao, George S. W.; Cheung, Siu Tim
	2017-06-10
Source Publication	BMC CANCER
ISSN	1471-2407
Volume	17
Abstract	Background: Granulin-epithelin precursor (GEP) is a secretory growth factor, which has been demonstrated to control cancer growth, invasion, drug resistance and immune escape. Our previous studies and others also demonstrated its potential in targeted therapy. Comprehensive characterization of GEP partner on cancer cells are warranted. We have previously shown that GEP interacted with heparan sulfate on the surface of liver cancer cells and the interaction is crucial for GEP-mediated signaling transduction. This study aims to characterize GEP protein partner at the cell membrane with the co-immunoprecipitation and mass spectrometry approach.
Keyword	Granulin-epithelin precursor 78-kDa glucose-regulated protein Hepatocellular carcinoma Mass spectrometry Protein interaction
DOI	10.1186/s12885-017-3399-x
URL	View the original
Indexed By	SCI
Language	英语
WOS Research Area	Oncology
WOS Subject	Oncology
WOS ID	WOS:000403379000001
Publisher	BIOMED CENTRAL LTD
The Source to Article	WOS
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics	Cited Times [WOS]:3 [WOS Record] [Related Records in WOS]
Document Type	Journal article
Collection	University of Macau
Recommended Citation GB/T 7714	Yip, Chi Wai,Lam, Ching Yan,Poon, Terence C. W.,et al. Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma[J]. BMC CANCER,2017,17.
APA	Yip, Chi Wai.,Lam, Ching Yan.,Poon, Terence C. W..,Cheung, Tan To.,Cheung, Phyllis F. Y..,...&Cheung, Siu Tim.(2017).Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.BMC CANCER,17.
MLA	Yip, Chi Wai,et al."Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma".BMC CANCER 17(2017).

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