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Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma
Chi Wai Yip1,2; Ching Yan Lam2,7; Terence C. W. Poon3; Tan To Cheung2; Phyllis F. Y. Cheung1,4; Sze Wai Fung1,2,5; Xiao Qi Wang2; Idy C. Y. Leung2; Linda W. C. Ng1; Chung Mau Lo2; George S. W. Tsao5; Siu Tim Cheung1,6,8
2017-06-10
Source PublicationBMC CANCER
ISSN1471-2407
Volume17
Abstract

Background: Granulin-epithelin precursor (GEP) is a secretory growth factor, which has been demonstrated to control cancer growth, invasion, drug resistance and immune escape. Our previous studies and others also demonstrated its potential in targeted therapy. Comprehensive characterization of GEP partner on cancer cells are warranted. We have previously shown that GEP interacted with heparan sulfate on the surface of liver cancer cells and the interaction is crucial for GEP-mediated signaling transduction. This study aims to characterize GEP protein partner at the cell membrane with the co-immunoprecipitation and mass spectrometry approach.

KeywordGranulin-epithelin Precursor 78-kda Glucose-regulated Protein Hepatocellular Carcinoma Mass Spectrometry Protein Interaction
DOI10.1186/s12885-017-3399-x
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000403379000001
PublisherBIOMED CENTRAL LTD
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorSiu Tim Cheung
Affiliation1.Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China
2.Department of Surgery, The University of Hong Kong, Hong Kong, China
3.Faculty of Health Sciences, University of Macau, Macau, China
4.Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
5.School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
6.Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
7.Department of Health, The Government of the Hong Kong Special Administrative Region, Hong Kong, China
8.Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Recommended Citation
GB/T 7714
Chi Wai Yip,Ching Yan Lam,Terence C. W. Poon,et al. Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma[J]. BMC CANCER,2017,17.
APA Chi Wai Yip.,Ching Yan Lam.,Terence C. W. Poon.,Tan To Cheung.,Phyllis F. Y. Cheung.,...&Siu Tim Cheung.(2017).Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.BMC CANCER,17.
MLA Chi Wai Yip,et al."Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma".BMC CANCER 17(2017).
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