UM
Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma
Yip, Chi Wai; Lam, Ching Yan; Poon, Terence C. W.; Cheung, Tan To; Cheung, Phyllis F. Y.; Fung, Sze Wai; Wang, Xiao Qi; Leung, Idy C. Y.; Ng, Linda W. C.; Lo, Chung Mau; Tsao, George S. W.; Cheung, Siu Tim
2017-06-10
Source PublicationBMC CANCER
ISSN1471-2407
Volume17
AbstractBackground: Granulin-epithelin precursor (GEP) is a secretory growth factor, which has been demonstrated to control cancer growth, invasion, drug resistance and immune escape. Our previous studies and others also demonstrated its potential in targeted therapy. Comprehensive characterization of GEP partner on cancer cells are warranted. We have previously shown that GEP interacted with heparan sulfate on the surface of liver cancer cells and the interaction is crucial for GEP-mediated signaling transduction. This study aims to characterize GEP protein partner at the cell membrane with the co-immunoprecipitation and mass spectrometry approach.
KeywordGranulin-epithelin precursor 78-kDa glucose-regulated protein Hepatocellular carcinoma Mass spectrometry Protein interaction
DOI10.1186/s12885-017-3399-x
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000403379000001
PublisherBIOMED CENTRAL LTD
The Source to ArticleWOS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Yip, Chi Wai,Lam, Ching Yan,Poon, Terence C. W.,et al. Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma[J]. BMC CANCER,2017,17.
APA Yip, Chi Wai.,Lam, Ching Yan.,Poon, Terence C. W..,Cheung, Tan To.,Cheung, Phyllis F. Y..,...&Cheung, Siu Tim.(2017).Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.BMC CANCER,17.
MLA Yip, Chi Wai,et al."Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma".BMC CANCER 17(2017).
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