Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma | |
Yip, Chi Wai; Lam, Ching Yan; Poon, Terence C. W.; Cheung, Tan To; Cheung, Phyllis F. Y.; Fung, Sze Wai; Wang, Xiao Qi; Leung, Idy C. Y.; Ng, Linda W. C.; Lo, Chung Mau; Tsao, George S. W.; Cheung, Siu Tim | |
2017-06-10 | |
Source Publication | BMC CANCER
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ISSN | 1471-2407 |
Volume | 17 |
Abstract | Background: Granulin-epithelin precursor (GEP) is a secretory growth factor, which has been demonstrated to control cancer growth, invasion, drug resistance and immune escape. Our previous studies and others also demonstrated its potential in targeted therapy. Comprehensive characterization of GEP partner on cancer cells are warranted. We have previously shown that GEP interacted with heparan sulfate on the surface of liver cancer cells and the interaction is crucial for GEP-mediated signaling transduction. This study aims to characterize GEP protein partner at the cell membrane with the co-immunoprecipitation and mass spectrometry approach. |
Keyword | Granulin-epithelin precursor 78-kDa glucose-regulated protein Hepatocellular carcinoma Mass spectrometry Protein interaction |
DOI | 10.1186/s12885-017-3399-x |
URL | View the original |
Indexed By | SCI |
Language | 英语 |
WOS Research Area | Oncology |
WOS Subject | Oncology |
WOS ID | WOS:000403379000001 |
Publisher | BIOMED CENTRAL LTD |
The Source to Article | WOS |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | University of Macau |
Recommended Citation GB/T 7714 | Yip, Chi Wai,Lam, Ching Yan,Poon, Terence C. W.,et al. Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma[J]. BMC CANCER,2017,17. |
APA | Yip, Chi Wai.,Lam, Ching Yan.,Poon, Terence C. W..,Cheung, Tan To.,Cheung, Phyllis F. Y..,...&Cheung, Siu Tim.(2017).Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.BMC CANCER,17. |
MLA | Yip, Chi Wai,et al."Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma".BMC CANCER 17(2017). |
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