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In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules
Li, Yunjie1; Hu, Xiaoxiao1; Ding, Ding1; Zou, Yuxiu1; Xu, Yiting1; Wang, Xuewei1; Zhang, Yin1; Chen, Long2; Chen, Zhuo1; Tan, Weihong1,3,4,5
2017-06-15
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume8
Abstract

Helicobacter pylori infection is implicated in the aetiology of many diseases. Despite numerous studies, a painless, fast and direct method for the in situ detection of H. pylori remains a challenge, mainly due to the strong acidic/enzymatic environment of the gastric mucosa. Herein, we report the use of stable magnetic graphitic nanocapsules (MGNs), for in situ targeted magnetic resonance imaging (MRI) detection of H. pylori. Several layers of graphene as the shell effectively protect the magnetic core from corrosion while retaining the superior contrast effect for MRI in the gastric environment. Boronic-polyethylene glycol molecules were synthesized and modified on the MGN surface for targeted MRI detection. In a mouse model of H. pylori-induced infection, H. pylori was specifically detected through both T-2-weighted MR imaging and Raman gastric mucosa imaging using functionalized MGNs. These results indicated that enhancement of MRI using MGNs may be a promising diagnostic and bioimaging platform for very harsh conditions.

DOI10.1038/ncomms15653
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000403316500001
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF COMPUTER AND INFORMATION SCIENCE
Affiliation1.Hunan Univ, Coll Biol, Coll Chem & Chem Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensi, Changsha 410082, Hunan, Peoples R China
2.Univ Macau, Fac Sci & Technol, Av Univ, Taipa 999078, Macau, Peoples R China
3.Univ Florida, Dept Chem, Gainesville, FL 32611 USA
4.Univ Florida, Dept Physiol & Funct Gen, Ctr Res Bionano Interface, Shands Canc Ctr,UF Genet Inst, Gainesville, FL 32611 USA
5.Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
Recommended Citation
GB/T 7714
Li, Yunjie,Hu, Xiaoxiao,Ding, Ding,et al. In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules[J]. NATURE COMMUNICATIONS,2017,8.
APA Li, Yunjie.,Hu, Xiaoxiao.,Ding, Ding.,Zou, Yuxiu.,Xu, Yiting.,...&Tan, Weihong.(2017).In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules.NATURE COMMUNICATIONS,8.
MLA Li, Yunjie,et al."In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules".NATURE COMMUNICATIONS 8(2017).
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