UM
Controlled H 2 O 2 release via long-lived electron-hole separation mediated to induce tumor cell apoptosis
Wang C.4; Gao X.3; Gao Y.4; Cao W.4; Tian J.4; Wu X.4; Ye Z.4; Zeng X.4; Zhou B.4; Wu J.4; Fang Z.3; Wan J.3; Qin J.2; Wen W.4
2015
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume3Issue:41Pages:8115-8122
AbstractFlexible films of polytungstate (PT) as active ingredients were fabricated in PDMS as a "band-Aid" to achieve controllable H O release. In these different systems of an amorphous PT building block, the lengthened lifetime (bleaching process) of photo-electron-hole separation is attributed to the electron trapping of the PT network and the existence of hole scavengers. The hole scavengers further prevent recombination of electrons and holes, so that the long-lived photoelectron could provide sustainable reactive oxygen species (ROS) by trapped electrons. Transient absorption illustrates the kinetic competition between the process of photohole induced bleaching and coloration induced by weak irradiation, which suggests that the hole scavenger is vital for ROS generation. The signals of electron spin resonance further confirm the existence of ROS. The profiles of controllable H O with various release efficiency were obtained via fluorescence studies. The results indicate that the H O release efficiency is related to both the hole scavenger and the tungstate cluster. The released H O on the responses of tumor cells were evaluated. Compared with a cancer drug, the controllable and reversible released H O delivery is highly efficient in preventing the proliferation and inducing apoptosis of A375 melanoma cells.
DOI10.1039/c5tb00186b
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong University of Science and Technology, Shenzhen Research Institute
2.Dalian Institute of Chemical Physics Chinese Academy of Sciences
3.Peking University
4.Hong Kong University of Science and Technology
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Wang C.,Gao X.,Gao Y.,et al. Controlled H 2 O 2 release via long-lived electron-hole separation mediated to induce tumor cell apoptosis[J]. Journal of Materials Chemistry B,2015,3(41):8115-8122.
APA Wang C..,Gao X..,Gao Y..,Cao W..,Tian J..,...&Wen W..(2015).Controlled H 2 O 2 release via long-lived electron-hole separation mediated to induce tumor cell apoptosis.Journal of Materials Chemistry B,3(41),8115-8122.
MLA Wang C.,et al."Controlled H 2 O 2 release via long-lived electron-hole separation mediated to induce tumor cell apoptosis".Journal of Materials Chemistry B 3.41(2015):8115-8122.
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