UM
Synergistic effect of sunlight induced photothermal conversion and H 2 O 2 release based on hybridized tungsten oxide gel for cancer inhibition
Wang C.6; Gao Y.1; Gao X.2; Wang H.3; Tian J.1; Wang L.1; Zhou B.1; Ye Z.1; Wan J.2; Wen W.1
2016-10-24
Source PublicationScientific Reports
ISSN20452322
Volume6
AbstractA highly efficient photochromic hydrogel was successfully fabricated via casting precursor, which is based on amorphous tungsten oxide and poly (ethylene oxide)-block-poly (propylene oxide)-block-poly (ethylene oxide). Under simulated solar illumination, the hydrogel has a rapid and controlled temperature increasing ratio as its coloration degree. Localized electrons in the amorphous tungsten oxide play a vital role in absorption over a broad range of wavelengths from 400 nm to 1100 nm, encompassing the entire visible light and infrared regions in the solar spectrum. More importantly, the material exhibits sustainable released H O induced by localized electrons, which has a synergistic effect with the rapid surface temperature increase. The amount of H O released by each film can be tuned by the light irradiation, and the film coloration can indicate the degree of oxidative stress. The ability of the H O -releasing gels in vitro study was investigated to induce apoptosis in melanoma tumor cells and NIH 3T3 fibroblasts. The in vivo experimental results indicate that these gels have a greater healing effect than the control in the early stages of tumor formation.
DOI10.1038/srep35876
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong University of Science and Technology
2.Shenzhen PKU-HKUST Medical Center
3.Renji Hospital
4.Shanghai University
5.Universidade de Macau
6.Beijing University of Technology
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Wang C.,Gao Y.,Gao X.,et al. Synergistic effect of sunlight induced photothermal conversion and H 2 O 2 release based on hybridized tungsten oxide gel for cancer inhibition[J]. Scientific Reports,2016,6.
APA Wang C..,Gao Y..,Gao X..,Wang H..,Tian J..,...&Wen W..(2016).Synergistic effect of sunlight induced photothermal conversion and H 2 O 2 release based on hybridized tungsten oxide gel for cancer inhibition.Scientific Reports,6.
MLA Wang C.,et al."Synergistic effect of sunlight induced photothermal conversion and H 2 O 2 release based on hybridized tungsten oxide gel for cancer inhibition".Scientific Reports 6(2016).
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