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Preparation of orthogonal physicochemical gradients on PDMS surface using microfluidic concentration gradient generator
Zhou B.2; Gao Y.3; Tian J.4; Tong R.3; Wu J.1; Wen W.3
2019-03-31
Source PublicationApplied Surface Science
ISSN01694332
Volume471Pages:213-221
Abstract

Recently, surface with desirable gradients has been proved to be a powerful tool for diverse applications from biological systems and chemical analysis to material science. In this work, we demonstrate a versatile and universal approach to realize controllable physicochemical properties in orthogonal gradients on polydimethylsiloxane (PDMS) surface. Based on a novel microfluidics network, we can easily establish the concentration gradients within the microfluidic channel for surface polymerization or chemical deposition to realize the stable characteristic gradient on the PDMS substrate. The method was introduced to prepare surface with two-dimensional physical (roughness) gradients, or combinational physicochemical gradients to study the synergistic effect on interested phenomenon. As a proof of concept, the experimental results show that the as-prepared substrate can effectively influence in various fields, such as protein adsorption and nano-particle immobilization, which can potentially be used for future systematical study in biological systems or practical applications in bio/chemical analysis/sensing.

KeywordOrthogonal Gradient Protein Adsorption Silver Nano-particle Surface Roughness
DOI10.1016/j.apsusc.2018.11.241
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Physics ; Materials Science
WOS SubjectChemistry, Physical ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000455471100023
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Applied Physics and Materials Engineering
Affiliation1.Shanghai University
2.Universidade de Macau
3.Hong Kong University of Science and Technology
4.The University of Hong Kong
Recommended Citation
GB/T 7714
Zhou B.,Gao Y.,Tian J.,et al. Preparation of orthogonal physicochemical gradients on PDMS surface using microfluidic concentration gradient generator[J]. Applied Surface Science,2019,471:213-221.
APA Zhou B.,Gao Y.,Tian J.,Tong R.,Wu J.,&Wen W..(2019).Preparation of orthogonal physicochemical gradients on PDMS surface using microfluidic concentration gradient generator.Applied Surface Science,471,213-221.
MLA Zhou B.,et al."Preparation of orthogonal physicochemical gradients on PDMS surface using microfluidic concentration gradient generator".Applied Surface Science 471(2019):213-221.
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