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Therapeutic Properties of Bioactive Compounds from Different Honeybee Products
Cornara, Laura1; Biagi, Marco2; Xiao, Jianbo3; Burlando, Bruno4
2017-06-28
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume8
Abstract

Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

KeywordBee Pollen Bee Venom Beeswax Honey Propolis Royal Jelly
DOI10.3389/fphar.2017.00412
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000404332300001
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Dipartimento di Scienze della Terra, dell’Ambiente e della Vita, Università degli Studi di Genova, Genova, Italy
2.Unità Operativa di Biologia Farmaceutica, Dipartimento di Scienze Fisiche, della Terra e dell’Ambiente, Università degli Studi di Siena, Siena, Italy
3.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macau
4.Dipartimento di Farmacia, Università degli Studi di Genova, Genova, Italy
Recommended Citation
GB/T 7714
Cornara, Laura,Biagi, Marco,Xiao, Jianbo,et al. Therapeutic Properties of Bioactive Compounds from Different Honeybee Products[J]. FRONTIERS IN PHARMACOLOGY,2017,8.
APA Cornara, Laura,Biagi, Marco,Xiao, Jianbo,&Burlando, Bruno.(2017).Therapeutic Properties of Bioactive Compounds from Different Honeybee Products.FRONTIERS IN PHARMACOLOGY,8.
MLA Cornara, Laura,et al."Therapeutic Properties of Bioactive Compounds from Different Honeybee Products".FRONTIERS IN PHARMACOLOGY 8(2017).
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