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Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury
Ren, Huixia1; Yang, Zhen2; Luo, Chuanming1; Zeng, Haitao3; Li, Peng1; Kang, Jing X.4; Wan, Jian-Bo1; He, Chengwei1; Su, Huanxing1
2017-07
Source PublicationMOLECULAR NEUROBIOLOGY
ISSN0893-7648
Volume54Issue:5Pages:3317-3326
Abstract

Currently no effective therapies are available for the treatment of traumatic brain injury (TBI). Early intervention that specifically provides neuroprotection is of most importance which profoundly influences the outcome of TBI. In the present study, we adopted a closed-skull mild TBI model to investigate potential roles of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in protecting against TBI. Using two-photon laser scanning microscopy (2PLSM), parenchymal cell death and reactive oxidative species (ROS) expression were directly observed and recorded after TBI through a thinned skull bone window. Fat-1 mice with high endogenous omega-3 PUFAs significantly inhibited ROS expression and attenuated parenchymal cell death after compression injury during the early injury phase. Elevated generation of glutathione (GSH) and neuroprotectin D1 (NPD1) in the parenchyma of fat-1 mice could be the contributor to the beneficial role of omega-3 PUFAs in TBI. The results of the study suggest that omega-3 PUFAs is an effective neuroprotectant as an early pharmacological intervention for TBI and the information derived from this study may help guide dietary advice for those who are susceptible to repetitive mild TBI.

KeywordTraumatic Brain Injury Omega-3 Polyunsaturated Fatty Acids Neuroprotection Two-photon Laser Scanning Microscopy Dha
DOI10.1007/s12035-016-9931-1
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000402100100020
PublisherHUMANA PRESS INC
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical SciencesUniversity of MacauMacaoChina
2.Department of Cardiology, The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouPeople’s Republic of China
3.Center for Reproductive Medicine, The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
4.Laboratory for Lipid Medicine and Technology, the Department of MedicineMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ren, Huixia,Yang, Zhen,Luo, Chuanming,et al. Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury[J]. MOLECULAR NEUROBIOLOGY,2017,54(5):3317-3326.
APA Ren, Huixia.,Yang, Zhen.,Luo, Chuanming.,Zeng, Haitao.,Li, Peng.,...&Su, Huanxing.(2017).Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury.MOLECULAR NEUROBIOLOGY,54(5),3317-3326.
MLA Ren, Huixia,et al."Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury".MOLECULAR NEUROBIOLOGY 54.5(2017):3317-3326.
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