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Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins
Cai, Yuee1; Zhang, Jinming1; Chen, Nelson G.2; Shi, Zhi3; Qiu, Jiange3; He, Chengwei1; Chen, Meiwan1
2017-07
Source PublicationMEDICINAL RESEARCH REVIEWS
ISSN0198-6325
Volume37Issue:4Pages:665-701
Abstract

Tannins, polyphenols in medicinal plants, have been divided into two groups of hydrolysable and condensed tannins, including gallotannins, ellagitannins, and (-)-epigallocatechin-3-gallate (EGCG). Potent anticancer activities have been observed in tannins (especially EGCG) with multiple mechanisms, such as apoptosis, cell cycle arrest, and inhibition of invasion and metastases. Furthermore, the combinational effects of tannins and anticancer drugs have been demonstrated in this review, including chemoprotective, chemosensitive, and antagonizing effects accompanying with anticancer effect. However, the applications of tannins have been hindered due to their poor liposolubility, low bioavailability, off-taste, and shorter half-life time in human body, such as EGCG, gallic acid, and ellagic acid. To tackle these obstacles, novel drug delivery systems have been employed to deliver tannins with the aim of improving their applications, such as gelatin nanoparticles, micelles, nanogold, liposomes, and so on. In this review, the chemical characteristics, anticancer properties, and drug delivery systems of tannins were discussed with an attempt to provide a systemic reference to promote the development of tannins as anticancer agents. (C) 2016 Wiley Periodicals, Inc.

KeywordTannins Anticancer (-)-epigallocatechin-3-gallate Combinatorial Effects Drug Delivery Systems
DOI10.1002/med.21422
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000402965100001
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, Meiwan
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, , Macau, China
2.Institute of Biomedical Engineering, Department of Electrical and Computer Engineering, National Chiao Tung University, , Hsinchu, Taiwan
3.Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, , Guangzhou, Guangdong 510632, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Cai, Yuee,Zhang, Jinming,Chen, Nelson G.,et al. Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins[J]. MEDICINAL RESEARCH REVIEWS,2017,37(4):665-701.
APA Cai, Yuee.,Zhang, Jinming.,Chen, Nelson G..,Shi, Zhi.,Qiu, Jiange.,...&Chen, Meiwan.(2017).Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins.MEDICINAL RESEARCH REVIEWS,37(4),665-701.
MLA Cai, Yuee,et al."Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins".MEDICINAL RESEARCH REVIEWS 37.4(2017):665-701.
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