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Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer
Wang, Yuan1; Hao, Da-Peng1; Li, Jing-Jing1; Wang, Li2; Di, Li-Jun1
2017-07-04
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:27Pages:44705-44719
Abstract

Enhancer is critical cis regulatory elements in gene expression. To understand whether and how the aberrant enhancer activation may contribute to cancer risk, the differentially methylated enhancers (eDMRs) in normal and malignant breast tissues were identified and analyzed. By incorporating genome-wide chromatin interaction, integrated analysis of eDMRs and target gene expression identified 1,272 enhancer-promoter pairs. Surprisingly, two functionally distinct groups of genes were identified in these pairs, one showing better correlation to enhancer methylation (eRGs) and the other showing better correlation to promoter methylation (pRGs), and the former group is functionally enriched with cancer related genes. Moreover, enhancer methylation based clustering of breast cancer samples is capable of discriminating basal breast cancer from other subtypes. By correlating enhancer methylation status to patient survival, 345 enhancers show the impact on the disease outcome and the majority of their target genes are important regulators of cell survival pathways including known cancer related genes. Together, these results suggest reactivation of enhancers in cancer cells has the add-on effect and contributes to cancer risk in combination.

KeywordEnhancer Methylation Breast Cancer Chromatin Interaction Polii Chia-pet Gene Regulation
DOI10.18632/oncotarget.18348
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000405498000089
PublisherIMPACT JOURNALS LLC
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Cancer Center, Faculty of Health Sciences, University of Macau, Macau, China
2.Metabolomics Core, Faculty of Health Sciences, University of Macau, Macau, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wang, Yuan,Hao, Da-Peng,Li, Jing-Jing,et al. Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer[J]. ONCOTARGET,2017,8(27):44705-44719.
APA Wang, Yuan,Hao, Da-Peng,Li, Jing-Jing,Wang, Li,&Di, Li-Jun.(2017).Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer.ONCOTARGET,8(27),44705-44719.
MLA Wang, Yuan,et al."Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer".ONCOTARGET 8.27(2017):44705-44719.
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