UM
Carbon dots as a trackable drug delivery carrier for localized cancer therapy: In vivo
Zeng Q.3; Shao D.1; He X.1; Ren Z.3; Ji W.3; Shan C.3; Qu S.3; Li J.1; Chen L.1; Li Q.2
2016
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume4Issue:30Pages:5119-5126
AbstractFluorescent carbon dots (CDs) with a size smaller than 10 nm, excellent biocompatibility, and low to no cytotoxicity are considered as a rising star in nanomedicine. In this report, for the first time we demonstrate that green-emitting CDs with a carboxyl-rich surface can be employed as a trackable drug delivery agent for localized cancer treatment in a mouse model. The CDs are conjugated with the cancer drug, Doxorubicin (DOX), via non-covalent bonding, utilizing the native carboxyl groups on CDs and the amine moiety on DOX molecules. The pH difference between cancer and normal cells was successfully exploited as the triggering mechanism for DOX release. Our in vivo study demonstrated that the fluorescent CDs can serve as a targeted drug delivery system for localized therapy, and the stimuli-responsive non-covalent bonding between the nanodot carrier and the drug molecule is sufficiently stable in complex biological systems. Taken together, our work provides a strategy to promote the potential clinical application of CDs in cancer theranostics.
DOI10.1039/c6tb01259k
URLView the original
Language英語
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Cited Times [WOS]:55   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Jilin University
2.Griffith University
3.Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences
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GB/T 7714
Zeng Q.,Shao D.,He X.,et al. Carbon dots as a trackable drug delivery carrier for localized cancer therapy: In vivo[J]. Journal of Materials Chemistry B,2016,4(30):5119-5126.
APA Zeng Q..,Shao D..,He X..,Ren Z..,Ji W..,...&Li Q..(2016).Carbon dots as a trackable drug delivery carrier for localized cancer therapy: In vivo.Journal of Materials Chemistry B,4(30),5119-5126.
MLA Zeng Q.,et al."Carbon dots as a trackable drug delivery carrier for localized cancer therapy: In vivo".Journal of Materials Chemistry B 4.30(2016):5119-5126.
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