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Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine
Zhang, Yulin; Liang, Yeer; He, Chengwei
2017-07-12
Source PublicationCHINESE MEDICINE
ISSN1749-8546
Volume12
Abstract

In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-clearing and detoxicating (HCD) herbs are essential components of TCM formulas for cancer treatment. An increasing interest has been focused on the study of HCD herbs and accumulated evidences have shown that HCD herbs or HCD herbs-based formulas exhibited remarkable anticancer effects when used alone or combined with other therapeutic approaches. Some of the HCD herb-derived products have been tested in clinical trials. Studies revealed that extracts or pure compounds of the HCD herbs showed a broad anticancer spectrum against both solid and hematologic malignancies without significant toxic effects. Notably, some HCD herbs or formulas could strongly enhance the anticancer activities of chemo-or radio-therapy and alleviate their side effects. The anticancer activities of HCD herb exacts or the pure compounds were reported to be through multiple cellular or molecular mechanisms, such as induction of cancer cell apoptosis, differentiation and cell cycle arrest, inhibition of cancer cell growth, invasion and metastasis, and inhibition of tumor angiogenesis. In this review, we provide comprehensive analysis and summary of research progress and future prospects in this field to facilitate the further study and application of HCD herbs.

KeywordTraditional Chinese Medicine Heat-clearing And Detoxicating Herbs Anticancer Cellular And Molecular Mechanisms
DOI10.1186/s13020-017-0140-2
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000405745000001
PublisherBIOMED CENTRAL LTD
The Source to ArticleWOS
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHe, Chengwei
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, N22-7038, Avenida da Universidade, Taipa, Macao, 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang, Yulin,Liang, Yeer,He, Chengwei. Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine[J]. CHINESE MEDICINE,2017,12.
APA Zhang, Yulin,Liang, Yeer,&He, Chengwei.(2017).Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine.CHINESE MEDICINE,12.
MLA Zhang, Yulin,et al."Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine".CHINESE MEDICINE 12(2017).
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