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Photosensitization Priming of Tumor Microenvironments Improves Delivery of Nanotherapeutics via Neutrophil Infiltration
Chu, Dafeng1; Dong, Xinyue1; Zhao, Qi2; Gu, Jingkai3; Wang, Zhenjia1
2017-07-19
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume29Issue:27
Abstract

Remodeling of tumor microenvironments enables enhanced delivery of nanoparticles (NPs). This study shows that direct priming of a tumor tissue using photosensitization rapidly activates neutrophil infiltration that mediates delivery of nanotherapeutics into the tumor. A drug delivery platform is comprised of NPs coated with anti-CD11b antibodies (Abs) that target activated neutrophils. Intravital microscopy demonstrates that the movement of anti-CD11b Abs-decorated NPs (NPs-CD11b) into the tumor is mediated by neutrophil infiltration induced by photosensitization (PS) because the systemic depletion of neutrophils completely abolishes the nanoparticle tumor deposition. The neutrophil uptake of NPs does not alter neutrophil activation and transmigration. For cancer therapy in mice, tumor PS and photothermal therapy of anti-CD11b Abs-linked gold nanorods (GNRs-CD11b) are combined to treat the carcinoma tumor. The result indicates that neutrophil tumor infiltration enhances nanoparticle cancer therapy. The findings reveal that promoting tumor infiltration of neutrophils by manipulating tumor microenvironments could be a novel strategy to actively deliver nanotherapeutics in cancer therapies.

KeywordCancer Therapy Nanoparticle Drug Delivery Neutrophil Infiltration Tumor Microenvironments Nanotherapeutics
DOI10.1002/adma.201701021
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000405410700026
PublisherWILEY-V C H VERLAG GMBH
The Source to ArticleWOS
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Cited Times [WOS]:39   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang, Zhenjia
Affiliation1.Washington State Univ, Coll Pharm, Dept Pharmaceut Sci, Spokane, WA 99210 USA
2.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
3.Jilin Univ, Res Ctr Drug Metab, Changchun 130021, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Chu, Dafeng,Dong, Xinyue,Zhao, Qi,et al. Photosensitization Priming of Tumor Microenvironments Improves Delivery of Nanotherapeutics via Neutrophil Infiltration[J]. ADVANCED MATERIALS,2017,29(27).
APA Chu, Dafeng,Dong, Xinyue,Zhao, Qi,Gu, Jingkai,&Wang, Zhenjia.(2017).Photosensitization Priming of Tumor Microenvironments Improves Delivery of Nanotherapeutics via Neutrophil Infiltration.ADVANCED MATERIALS,29(27).
MLA Chu, Dafeng,et al."Photosensitization Priming of Tumor Microenvironments Improves Delivery of Nanotherapeutics via Neutrophil Infiltration".ADVANCED MATERIALS 29.27(2017).
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