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Post-screening characterisation and in viva evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides
Li, Qiu1; Feng, Yanxian1; He, Wei1,2; Wang, Lintao2; Wang, Ruibing1; Dong, Lei1; Wang, Chunming1
2017-08
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume169Pages:304-314
Abstract

We report here the discovery of a polysaccharide, namely EUP1, with anti-inflammatory activity from the herb of Eucommia ulmoides Oliv. We separated three polysaccharide fractions from this herb based on acidity and screened them for their activity in modulating the phenotype of murine macrophages. Among them, EUP1 was the only fraction to exert such a function it stimulated Raw 264.7 cells to express CD206 and a key anti-inflammatory cytokine interleukin-10. Having fully characterised EUP1 with a series of chromatographic and spectroscopic analyses, we evaluated its anti-inflammatory effects in both in vitro and in vivo inflammatory models. In the murine model of sepsis induced by lipopolysaccharide, administration of EUP1 effectively suppressed the expression of major inflammatory cytokines, alleviated lung injury and increased animal survival rate. In summary, EUP1, with a clearly elucidated chemical structure and solid anti-inflammatory activity, may become a valuable candidate for further development into an anti-septic therapeutic agent. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordPolysaccharides Carbohydrate Structure Anti-inflammation Anti-septic Eucommia Ulmoides
DOI10.1016/j.carbpol.2017.04.034
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000402343000035
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Chunming
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
2.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Qiu,Feng, Yanxian,He, Wei,et al. Post-screening characterisation and in viva evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides[J]. CARBOHYDRATE POLYMERS,2017,169:304-314.
APA Li, Qiu.,Feng, Yanxian.,He, Wei.,Wang, Lintao.,Wang, Ruibing.,...&Wang, Chunming.(2017).Post-screening characterisation and in viva evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides.CARBOHYDRATE POLYMERS,169,304-314.
MLA Li, Qiu,et al."Post-screening characterisation and in viva evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides".CARBOHYDRATE POLYMERS 169(2017):304-314.
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