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C-21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells
Qian, Xicheng; Li, Baocai; Li, Peng; Wang, Dong; Dai, Weifeng; Zhang, Mi
2017-08
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume140Pages:1-15
AbstractTwenty-three undescribed previously C-21 steroidal glycosides, named saccatols D-K and cynsaccatols I-W, together with six known analogs were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Apocynaceae). Their structures were elucidated by a variety of spectroscopic techniques, as well as HRESIMS and GC method. All isolated compounds were tested their neuroprotective effects on the model of H2O2-induced damage to PC12 cells. Except saccatols D-F, J, cynsaccatol V and wilfoside A, other twenty-three isolates produced significantly activities against H2O2-induced cell damage (P < 0.001). Furthermore, cynsaccatols I, N, O and S can obvious inhibition of damaged PC12 cell apoptosis at their dosages of 1 mu M by Annexin V-FITC/PI double staining assay with flow cytometry. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordCynanchum auriculatum Apocynaceae C-21 steroidal glycosides Neuroprotecton PC12 Apoptosis
DOI10.1016/j.phytochem.2017.04.014
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000403993200001
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Qian, Xicheng,Li, Baocai,Li, Peng,et al. C-21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells[J]. PHYTOCHEMISTRY,2017,140:1-15.
APA Qian, Xicheng,Li, Baocai,Li, Peng,Wang, Dong,Dai, Weifeng,&Zhang, Mi.(2017).C-21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells.PHYTOCHEMISTRY,140,1-15.
MLA Qian, Xicheng,et al."C-21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells".PHYTOCHEMISTRY 140(2017):1-15.
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