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Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan
Wu, Zheng-Feng1; Bao, Han1; Zhou, Fa-Yang1; Liu, Jing-Xin1; Meng, Fan-Cheng1; Feng, Lu2; Lu, Jin-Jian1; Zhang, Qing-Wen1; Ye, Yang2; Lin, Li-Gen1
2017-08
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume28Issue:8Pages:1711-1715
Abstract

Phytochemical investigation on the seeds of Caesalpinia sappan led to the isolation of five new cassane-type diterpenoids, named 11-oxo-phanginin A (1), caesalsappanins O-Q (2-4) and phanginin U (5), together with five known compounds. The structures of the new compounds were elucidated by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the new compounds showed moderate cytotoxic effects on human breast cancer MCF-7 and human colon cancer HCT116 cell lines. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

KeywordCaesalpinia Sappan Cassane Diterpenoid Phanginin Caesalsappanin Cytotoxicity
DOI10.1016/j.cclet.2017.04.023
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000407411600014
PublisherELSEVIER SCIENCE INC
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
2.State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai 201203, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wu, Zheng-Feng,Bao, Han,Zhou, Fa-Yang,et al. Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan[J]. CHINESE CHEMICAL LETTERS,2017,28(8):1711-1715.
APA Wu, Zheng-Feng.,Bao, Han.,Zhou, Fa-Yang.,Liu, Jing-Xin.,Meng, Fan-Cheng.,...&Lin, Li-Gen.(2017).Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan.CHINESE CHEMICAL LETTERS,28(8),1711-1715.
MLA Wu, Zheng-Feng,et al."Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan".CHINESE CHEMICAL LETTERS 28.8(2017):1711-1715.
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