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Natural products to prevent drug resistance in cancer chemotherapy: a review
Yuan, Renyikun; Hou, Ying; Sun, Wen; Yu, Jie; Liu, Xin; Niu, Yanan; Lu, Jin-Jian; Chen, Xiuping
2017-08
Source PublicationANNALS OF THE NEW YORK ACADEMY OF SCIENCES
ISSN0077-8923
Volume1401Issue:1Pages:19-27
Abstract

Chemotherapy is the standard internal medical treatment for cancer. However, the resistance of cancer cells to nearly all kinds of chemotherapeutic drugs and targeted drugs has become prevalent, and approximately 80-90% of deaths in cancer patients are directly or indirectly attributed to drug resistance. The progress of new drug research and development has also been impeded by the occurrence of drug resistance, which has emerged as a considerable challenge in cancer therapy. Fortunately, natural products with diverse chemical structures and pharmacological effects serve as effective substances against drug resistance. Since the discovery of a series of drug-resistant proteins, drug-efflux inhibition has been applied as the primary strategy to overcome drug resistance by maintaining the intracellular concentrations of chemotherapeutic drugs. Nonapoptotic cell death is considered an alternative strategy because most cases of drug resistance result in evasion and insensitivity to apoptosis. In this concise review, we summarize two strategies using natural products against drug resistance.

KeywordDrug Resistance Cancer Natural Products Nonapoptotic Cell Death
DOI10.1111/nyas.13387
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000410108700002
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yuan, Renyikun,Hou, Ying,Sun, Wen,et al. Natural products to prevent drug resistance in cancer chemotherapy: a review[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,2017,1401(1):19-27.
APA Yuan, Renyikun.,Hou, Ying.,Sun, Wen.,Yu, Jie.,Liu, Xin.,...&Chen, Xiuping.(2017).Natural products to prevent drug resistance in cancer chemotherapy: a review.ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,1401(1),19-27.
MLA Yuan, Renyikun,et al."Natural products to prevent drug resistance in cancer chemotherapy: a review".ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1401.1(2017):19-27.
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