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Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems
Jiang, Nan; Tang, Le; Xie, Ruiqiang; Li, Zhi; Burkinshaw, Brianne; Liang, Xiaoye; Sosa, Dylan; Aravind, L.; Dong, Tao; Zhang, Dapeng; Zheng, Jun
2018-09-25
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume9
AbstractType VI secretion systems (T6SSs) translocate effector proteins, such as Rhs toxins, to eukaryotic cells or prokaryotic competitors. All T6SS Rhs-type effectors characterized thus far contain a PAAR motif or a similar structure. Here, we describe a T6SS-dependent delivery mechanism for a subset of Rhs proteins that lack a PAAR motif. We show that the N-terminal Rhs domain of protein RhsP (or VP1517) from Vibrio parahaemolyticus inhibits the activity of the C-terminal DNase domain. Upon auto-proteolysis, the Rhs fragment remains inside the cells, and the C-terminal region interacts with PAAR2 and is secreted by T6SS2; therefore, RhsP acts as a pro-effector. Furthermore, we show that RhsP contributes to the control of certain "social cheaters" (opaR mutants). Genes encoding proteins with similar Rhs and PAAR-interacting domains, but diverse C-terminal regions, are widely distributed among Vibrio species.
DOI10.1038/s41467-018-06201-5
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000445560800007
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Jiang, Nan,Tang, Le,Xie, Ruiqiang,et al. Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems[J]. NATURE COMMUNICATIONS,2018,9.
APA Jiang, Nan.,Tang, Le.,Xie, Ruiqiang.,Li, Zhi.,Burkinshaw, Brianne.,...&Zheng, Jun.(2018).Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems.NATURE COMMUNICATIONS,9.
MLA Jiang, Nan,et al."Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems".NATURE COMMUNICATIONS 9(2018).
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